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Table 3 Relation between differentially methylated genes and downstream expressed genes of blastocysts originating from oocytes exposed to high NEFA concentrations

From: Exposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts

Associated pathways Differentially methylated genes Downstream differentially expressed genes
Apoptosis TP53 SIRT1, MAD2L1, FAM3C, CDC7, CD47, HERC5, HSPD1,SCP2, UBL3, ID3
Embryo implantation LIF GPCPD1, CYP11A1
Gene transcription CTBP1 SIRT 1
IGF1R PDCD10, SCP2, KRT19, CYP11A1
Immune response TCR HERC5, HSPD1, GBP4, ID3
RXRB CCL17
Metabolism G6PC CYP11A1
LEP SC4MOL, SCP2, TIMP1
PEPCK CYP11A1