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Table 5 Relation between differentially methylated genes and downstream expressed genes of blastocysts originating from embryos exposed to high NEFA concentrations

From: Exposure of bovine oocytes and embryos to elevated non-esterified fatty acid concentrations: integration of epigenetic and transcriptomic signatures in resultant blastocysts

Associated pathways Differentially methylated genes Downstream differentially expressed genes
Apoptosis TP53 SERPINE1, DCTN2, CNN3, BHLHB2, MTDH, ASNS, GLB1, CNN1, HMGCS1, CCND2, LBR, ANKH, NANOG, SEC61B, HSPG2, COX7A2, GZMB, IGFBP7
Autophagy ATG16L1 UPK1A
Cell cycle TERF2 GLB1
Cell differentiation FGFR2 CCND2, NANOG, NR5A2
Cell interaction Alpha catenin RHOC, IGFBP7, TWIST2
Cell signaling ERK1/2 SERPINE1, CCND2, LDLR, NANOG, RHOC
ITGAV SERPINE1, LDLR
Cell survival FGF10 SCD, LDLR, LFNG
Cellular development THPO CCND2, GP1BA
Hormonal regulation estrogen receptor SERPINE1, CCND2, LDLR, MUC1
FSH SERPINE1, CCND2, LDLR, AQP3, ARL4C, GZMB, CARD10, DUSP14, GATA4
FSHR GATA4, GZMB∆
Immune response CD28 TOM1L1, CCND2, TXNRD1, PA2G4, AQP3, SEC61B, RHOC, GZMB, DUSP14
Cg BHLHB2, CCND2, LDLR, S100A10, NR5A2, GATA4
TCR LBR, PA2G4, GZMB, ARPP21, LMNB1
Ion transport WNK1 SERPINE1
Gene transcription Creb MIF, HSPB8, LDLR, ELL
PRDM16 SERPINE1
SMARCA4 SERPINE1, MUC1, ASNS, FLNB, TXNRD1, ARL4C