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Table 2 Significantly differentially expressed genes in young endurance athletes as compared with non-athlete controls

From: Immune adaptation to chronic intense exercise training: new microarray evidence

Gene Symbol FC ibmt p-value FDR Gene Description
SNORD14E 2.00 2.02E-05 2.02E-02 small nucleolar RNA, C/D box 14E
CKS2 1.82 4.56E-06 1.65E-02 CDC28 protein kinase regulatory subunit 2
SNORD4B 1.74 3.89E-06 1.65E-02 small nucleolar RNA, C/D box 4B
HLA-DPB1 1.58 4.40E-05 2.29E-02 major histocompatibility complex, class II, DP beta 1
ATP5G1 1.53 3.28E-05 2.02E-02 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1
DDT 1.51 6.90E-05 3.09E-02 D-dopachrome tautomerase
TMEM141 1.51 3.71E-05 2.13E-02 transmembrane protein 141
BST2 1.50 1.39E-04 3.85E-02 bone marrow stromal cell antigen 2
LSM3 1.49 2.79E-05 2.02E-02 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
COX7B 1.49 1.35E-04 3.78E-02 cytochrome c oxidase subunit VIIb
RPL10A 1.49 1.12E-04 3.78E-02 ribosomal protein L10a
RPL21 1.46 9.21E-05 3.74E-02 ribosomal protein L21
HNRNPC 1.45 2.48E-05 2.02E-02 heterogeneous nuclear ribonucleoprotein C (C1/C2)
MLLT4 1.45 1.77E-04 4.46E-02 myeloid/lymphoid or mixed-lineage leukemia
RPS27 1.44 1.12E-04 3.78E-02 ribosomal protein S27
RPS19 1.43 2.29E-04 4.70E-02 ribosomal protein S19
MRPL51 1.42 4.08E-05 2.20E-02 mitochondrial ribosomal protein L51
FASTKD3 1.42 2.00E-04 4.52E-02 FAST kinase domains 3
RPLP0 1.41 2.17E-04 4.69E-02 ribosomal protein, large, P0
MIR15B 1.41 1.89E-04 4.46E-02 microRNA 15b
UQCR10 1.41 1.10E-06 1.15E-02 ubiquinol-cytochrome c reductase, complex III subunit X
RAB33A 1.40 5.50E-06 1.65E-02 RAB33A, member RAS oncogene family
RPL23 1.40 6.30E-05 2.96E-02 ribosomal protein L23
EDF1 1.40 3.02E-05 2.02E-02 endothelial differentiation-related factor 1
RPL36A 1.40 2.25E-04 4.70E-02 ribosomal protein L36a
RPL31 1.38 1.31E-04 3.78E-02 ribosomal protein L31
RPS18P9 1.38 1.29E-04 3.78E-02 ribosomal protein S18 pseudogene 9
CD79B 1.38 2.72E-05 2.02E-02 CD79b molecule, immunoglobulin-associated beta
RPL6 1.37 6.25E-06 1.65E-02 ribosomal protein L6
SEC61G 1.37 1.08E-04 3.78E-02 Sec61 gamma subunit
SF3B5 1.37 8.80E-06 1.65E-02 splicing factor 3b, subunit 5, 10 kDa
TPI1 1.37 8.13E-06 1.65E-02 triosephosphate isomerase 1
MRPL28 1.37 2.08E-06 1.15E-02 mitochondrial ribosomal protein L28
ACOT13 1.36 2.26E-05 2.02E-02 acyl-CoA thioesterase 13
SNHG12 1.35 2.28E-04 4.70E-02 small nucleolar RNA host gene 12 (non-protein coding)
C15orf57 1.35 3.05E-05 2.02E-02 chromosome 15 open reading frame 57
BEX4 1.35 1.24E-04 3.78E-02 brain expressed, X-linked 4
TMEM223 1.34 9.57E-05 3.74E-02 transmembrane protein 223
PSMG3 1.34 1.12E-05 1.65E-02 proteasome (prosome, macropain) assembly chaperone 3
MZT2A 1.34 2.25E-04 4.70E-02 mitotic spindle organizing protein 2A
LIPT1 1.34 9.42E-05 3.74E-02 lipoyltransferase 1
ATP5J 1.33 1.93E-06 1.15E-02 ATP synthase, H+ transporting, mitochondrial Fo complex
HSF5 1.33 1.32E-04 3.78E-02 heat shock transcription factor family member 5
CCDC72 1.33 3.52E-05 2.11E-02 coiled-coil domain containing 72
RPP21 1.32 8.65E-05 3.69E-02 ribonuclease P/MRP 21 kDa subunit
THYN1 1.32 1.09E-05 1.65E-02 thymocyte nuclear protein 1
SNRPG 1.32 1.17E-04 3.78E-02 small nuclear ribonucleoprotein polypeptide G
C1orf220 1.32 1.20E-04 3.78E-02 chromosome 1 open reading frame 220
SSBP2 1.31 3.20E-05 2.02E-02 single-stranded DNA binding protein 2
DPY30 1.31 1.10E-05 1.65E-02 dpy-30 homolog (C. elegans)
COX4I1 1.31 1.89E-06 1.15E-02 cytochrome c oxidase subunit IV isoform 1
C14orf2 1.31 8.66E-05 3.69E-02 chromosome 14 open reading frame 2
C13orf27 1.30 6.09E-05 2.96E-02 chromosome 13 open reading frame 27
C6orf226 1.30 1.89E-04 4.46E-02 chromosome 6 open reading frame 226
NDUFA12 1.30 6.42E-05 2.96E-02 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
MRPS11 1.30 2.28E-05 2.02E-02 mitochondrial ribosomal protein S11
CCDC56 1.30 2.05E-05 2.02E-02 coiled-coil domain containing 56
NDUFA2 1.30 1.77E-04 4.46E-02 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8 kDa
PFDN1 1.30 1.82E-04 4.46E-02 prefoldin subunit 1
PDE6D 1.30 2.69E-05 2.02E-02 phosphodiesterase 6D, cGMP-specific, rod, delta
SENP1 1.29 6.98E-05 3.09E-02 SUMO1/sentrin specific peptidase 1
MIF 1.28 2.72E-05 2.02E-02 macrophage migration inhibitory factor
NCRNA00188 1.28 1.34E-04 3.78E-02 non-protein coding RNA 188
MRPS33 1.28 1.98E-04 4.52E-02 mitochondrial ribosomal protein S33
IFI27L2 1.27 9.80E-05 3.74E-02 interferon, alpha-inducible protein 27-like 2
ATP5H 1.27 3.10E-05 2.02E-02 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ZNF140 1.27 3.84E-05 2.13E-02 zinc finger protein 140
ATP5F1 1.27 2.29E-05 2.02E-02 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
SKP2 1.26 1.04E-04 3.78E-02 S-phase kinase-associated protein 2 (p45)
ZNF786 1.25 2.57E-05 2.02E-02 zinc finger protein 786
TUBB4Q 0.78 1.41E-04 3.85E-02 tubulin, beta polypeptide 4, member Q
PIM2 0.74 2.42E-04 4.91E-02 pim-2 oncogene
  1. Significantly differentially expressed genes having a false discovery rates (FDRs, significance statistic adjusted for multiple testing) of ≤0.05 from an intensity-based Bayesian moderated t-test (IBMT) are shown. FC, fold change, calculated as the ratio of mRNA levels (athletes/controls)