Table 1 Selected genes enriched in differentially expressed transcripts nude and E14 skin and relevant functional categories. For epidermis the analysis relays on the comparison of genes differently regulated between nude and B6

 Zymogen

× (1.2 × 10⁻⁸)

× (4.5 × 10⁻⁹)

 Endopeptidase activity

× (7.1 × 10⁻²)

× (9.3 × 10⁻²)

 Metallopeptidase

× (2.3 × 10⁻²)

× (2.4 × 10⁻³)

 Protease

× (5.0 × 10⁻⁵)

× (1.5 × 10⁻⁶)

  Klk10, kallikrein related-peptidase 10

10.66

63.36

2.61

  Klk7, kallikrein related-peptidase 7

11.14

10.95

2.15

  Klk8, kallikrein related-peptidase 8

3.22

4.26

  Prss27, protease serine 27

8.68

29.83

5.19

 Keratinization

× (3.8 × 10⁻²)

× (8.9 × 10⁻⁴)

× (4.9 × 10⁻²)

 Keratin

× (3.2 × 10⁻⁸)

 Cornified envelope

× (4.6 × 10⁻⁵)

× (3.9 × 10⁻⁷)

× (1.6 × 10⁻⁸)

 Keratinocyte differentiation

× (1.5 × 10⁻²)

× (1.8 × 10⁻⁴)

× (1.9 × 10⁻⁴)

  Krt23, keratin 23

12.06

7.86

  Krt73, keratin 73

8.35

17.89

3.85

  Krt82, keratin 82

2.8

3.25

2.2

  Krt17, keratin 17

9.14

27.58

2.61

  Krt16, keratin 16

13.3

33.43

3.69

  Sprr2d, small proline-rich protein

15.66

12.88

4.71

  Flg2, filaggrin family member 2

21.31

  Rptn, repetin

4.65

34.82

3.85

  Ivl, involucrin

14.62

6.9

4.45

 Inflammatory response

× (1.8 × 10⁻⁷)

× (8.3 × 10⁻¹³)

× (2.8 × 10⁻²)

 Chemokine activity

× (1.7 × 10⁻⁵)

× (6.2 × 10⁻⁶)

× (8.6 × 10⁻²)

 Positive regulation of T cell differentiation

× (5.2 × 10⁻³)

× (1.9 × 10⁻²)

  Fn1, fibronectin 1

2.49

2.77

  Il-18, interleukin 18

7.47

5.07

  Il-1A, interleukin 1 alpha

6.32

7.75

  Il-1 F6, interleukin-1 epsilon (Il1e)

13.67

12.27

4.34

  Il-1 F8, interleukin 1 family, member 8

9.67

10.45

4.15

  Il-5, interleukin 5

2.5

3.14

 Differentiation

× (2.3 × 10⁻⁴)

× (1.6 × 10⁻⁴)

× (1.5 × 10⁻³)

 Developmental protein

× (5.8 × 10⁻¹¹)

× (3.0 × 10⁻¹⁷)

× (2.8 × 10⁻²)

  Foxd1, forkhead box D1

4.47

4.32

  Gbx2, gastrulation brain homeobox 2

18.2

7.65

  Hoxb3, homeobox B3. transcript variant 2

4.08

2.41

  Hoxb5, homeobox B5

5.83

3.7

  Hoxc6, homeobox C6

3.66

9.66

  Hoxd13, homeobox D13

6.33

5.39

  Pax1, paired box gene 1

8.94

9.47

  Phox2b, paired-like homeobox 2b

7.11

9.39

  Pitx1, paired-like homeodomain transcription factor 1

6.57

7.34

  Six1, sine oculis-related homeobox1 homolog (Drosophila)

4.07

8.29

  Six2, six2. complete sequence

15.18

10.96