Skip to main content

Table 3 Select pathways in common between viral NS1-2 transfected cells and MNV infected cells

From: Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes

Gene

HuNoV NS1-2

MNV NS1-2

MNV infected

NFkB signalling

 Card11

−1.34

aNS

−0.88

 Traf1

2.72

0.09

3.13

 Ptgs2

2.01

0.19

2.29

 Nfkb2

1.22

0.13

1.55

 Relb

1.29

aNS

2.49

 Ddx58

2.97

0.32

1.75

 Tnfaip3

1.00

0.05

3.26

MAPK signaling

 Fgf13

−1.50

−0.10

−0.09

 Myc

5.28

aNS

5.06

 Mef2c

−1.27

−0.13

−0.22

 Cacna1d

−3.04

−0.36

−0.86

 Gadd45g

−1.21

−0.14

1.29

 Dusp5

1.93

0.03

3.35

 Dusp4

1.46

0.30

1.85

 Dusp2

1.48

0.11

2.38

 Nfatc1

1.36

0.12

0.70

 Ptpn5

1.76

0.42

1.23

PI3K-Akt signaling

 Pkn3

1.20

0.25

0.54

 Igf1

−2.58

−0.14

−0.30

 Itgb5

−1.40

−0.03

−0.36

 Lamc2

3.19

0.81

5.77

 Creb3l2

1.29

0.28

1.23

 Efna1

2.06

−0.13

−1.32

 Pck2

1.08

0.19

0.45

 Itga5

1.38

0.10

1.33

 Lck

1.44

0.39

0.68

TLR signaling

 Ikbke

1.24

0.35

1.13

 TLR8

−2.84

−0.20

−2.18

 TLR9

−1.04

−0.04

−0.57

 TLR4

−0.86

aNS

−0.47

 TLR7

−0.88

aNS

−0.28

 TLR13

−1.58

aNS

−0.68

 IRF9

2.09

0.15

1.80

 IRF7

4.51

aNS

2.88

 IRF3

0.19

0.01

0.26

 IRF1

−0.46

−0.1

−0.36

Apoptosis

 Fas

1.79

1.19

2.83

 Capn2

1.07

0.04

0.21

 IL1rap

1.11

0.08

1.12

 IRAK2

1.19

0.18

1.97

 Mlkl

1.56

0.32

0.29

 Tnfrsf1b

−1.76

−0.07

−0.70

Metabolic pathways

 Fut7

−1.24

−0.14

−0.39

 Ppt1

−1.06

−0.14

−0.07

 Pla2g2d

1.53

0.18

0.73

 Khk

−1.07

−0.23

−0.36

 Ptgs1

−1.28

−0.07

−0.58

 Pck2

1.08

0.19

0.45

 Kmo

−4.09

−0.35

−1.64

 Agpat4

1.46

0.11

1.34

 Acy1

1.23

0.15

0.30

 Il4i1

−1.67

−0.26

−0.03

 Cth

2.61

0.54

1.91

 Xdh

−2.46

aNS

−0.90

 Acsbg1

1.76

0.08

0.63

 St6gal1

−2.42

−0.08

−1.19

 Dgkg

−2.86

−0.03

−0.68

 Ugt1a7c

−1.22

−0.02

−0.22

 Ak4

1.06

0.14

−0.27

 Kdsr

−1.23

−0.15

−0.60

 Acss2

−1.24

−0.02

−0.32

 Mthfd2

1.19

0.04

0.59

 Dhrs3

−1.90

aNS

−1.00

 Dcxr

−1.02

−0.25

−0.36

 Bdh2

1.96

0.32

0.98

 Lpin3

1.22

−0.06

0.77

 Gamt

−1.31

−0.06

−0.55

 Akr1b8

1.45

0.15

0.69

 Hpgds

−3.35

−0.04

−0.37

 Alox5

−2.69

−0.06

−0.65

Chemokine and cytokine signaling

 CCL2

2.24

0.34

9.53

 CCL3

1.01

0.03

2.22

 CCL5

6.45

0.18

bND

 CXCL2

4.01

0.89

7.38

 CCR1

2.53

0.50

1.20

 CXCR3

1.09

0.11

0.09

 CXCR4

−2.96

−0.14

−0.14

 CX3CR1

−1.74

aNS

−0.43

 TNF

1.85

0.11

2.54

 Lif

2.28

0.52

3.48

 Bcl3

1.25

0.40

1.54

 Ifnar2

−1.24

−0.03

−0.55

 Vegfa

1.60

0.09

0.79

 Il10ra

−1.91

aNS

−1.43

 Csf3r

−8.20

−0.27

−1.00

  1. Positive logFC numbers indicate upregulation, and negative numbers are downregulated genes when compared to mock-treated and cells only samples
  2. a NS: gene detected, but FC not significant
  3. b ND: not detected