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Table 3 Select pathways in common between viral NS1-2 transfected cells and MNV infected cells

From: Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes

Gene HuNoV NS1-2 MNV NS1-2 MNV infected
NFkB signalling
 Card11 −1.34 aNS −0.88
 Traf1 2.72 0.09 3.13
 Ptgs2 2.01 0.19 2.29
 Nfkb2 1.22 0.13 1.55
 Relb 1.29 aNS 2.49
 Ddx58 2.97 0.32 1.75
 Tnfaip3 1.00 0.05 3.26
MAPK signaling
 Fgf13 −1.50 −0.10 −0.09
 Myc 5.28 aNS 5.06
 Mef2c −1.27 −0.13 −0.22
 Cacna1d −3.04 −0.36 −0.86
 Gadd45g −1.21 −0.14 1.29
 Dusp5 1.93 0.03 3.35
 Dusp4 1.46 0.30 1.85
 Dusp2 1.48 0.11 2.38
 Nfatc1 1.36 0.12 0.70
 Ptpn5 1.76 0.42 1.23
PI3K-Akt signaling
 Pkn3 1.20 0.25 0.54
 Igf1 −2.58 −0.14 −0.30
 Itgb5 −1.40 −0.03 −0.36
 Lamc2 3.19 0.81 5.77
 Creb3l2 1.29 0.28 1.23
 Efna1 2.06 −0.13 −1.32
 Pck2 1.08 0.19 0.45
 Itga5 1.38 0.10 1.33
 Lck 1.44 0.39 0.68
TLR signaling
 Ikbke 1.24 0.35 1.13
 TLR8 −2.84 −0.20 −2.18
 TLR9 −1.04 −0.04 −0.57
 TLR4 −0.86 aNS −0.47
 TLR7 −0.88 aNS −0.28
 TLR13 −1.58 aNS −0.68
 IRF9 2.09 0.15 1.80
 IRF7 4.51 aNS 2.88
 IRF3 0.19 0.01 0.26
 IRF1 −0.46 −0.1 −0.36
Apoptosis
 Fas 1.79 1.19 2.83
 Capn2 1.07 0.04 0.21
 IL1rap 1.11 0.08 1.12
 IRAK2 1.19 0.18 1.97
 Mlkl 1.56 0.32 0.29
 Tnfrsf1b −1.76 −0.07 −0.70
Metabolic pathways
 Fut7 −1.24 −0.14 −0.39
 Ppt1 −1.06 −0.14 −0.07
 Pla2g2d 1.53 0.18 0.73
 Khk −1.07 −0.23 −0.36
 Ptgs1 −1.28 −0.07 −0.58
 Pck2 1.08 0.19 0.45
 Kmo −4.09 −0.35 −1.64
 Agpat4 1.46 0.11 1.34
 Acy1 1.23 0.15 0.30
 Il4i1 −1.67 −0.26 −0.03
 Cth 2.61 0.54 1.91
 Xdh −2.46 aNS −0.90
 Acsbg1 1.76 0.08 0.63
 St6gal1 −2.42 −0.08 −1.19
 Dgkg −2.86 −0.03 −0.68
 Ugt1a7c −1.22 −0.02 −0.22
 Ak4 1.06 0.14 −0.27
 Kdsr −1.23 −0.15 −0.60
 Acss2 −1.24 −0.02 −0.32
 Mthfd2 1.19 0.04 0.59
 Dhrs3 −1.90 aNS −1.00
 Dcxr −1.02 −0.25 −0.36
 Bdh2 1.96 0.32 0.98
 Lpin3 1.22 −0.06 0.77
 Gamt −1.31 −0.06 −0.55
 Akr1b8 1.45 0.15 0.69
 Hpgds −3.35 −0.04 −0.37
 Alox5 −2.69 −0.06 −0.65
Chemokine and cytokine signaling
 CCL2 2.24 0.34 9.53
 CCL3 1.01 0.03 2.22
 CCL5 6.45 0.18 bND
 CXCL2 4.01 0.89 7.38
 CCR1 2.53 0.50 1.20
 CXCR3 1.09 0.11 0.09
 CXCR4 −2.96 −0.14 −0.14
 CX3CR1 −1.74 aNS −0.43
 TNF 1.85 0.11 2.54
 Lif 2.28 0.52 3.48
 Bcl3 1.25 0.40 1.54
 Ifnar2 −1.24 −0.03 −0.55
 Vegfa 1.60 0.09 0.79
 Il10ra −1.91 aNS −1.43
 Csf3r −8.20 −0.27 −1.00
  1. Positive logFC numbers indicate upregulation, and negative numbers are downregulated genes when compared to mock-treated and cells only samples
  2. a NS: gene detected, but FC not significant
  3. b ND: not detected