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Table 1 Top 50 regions in terms of recurrence score identified by our method. We give the position of the region, number of genomes that are mutated within the region, the recurrence score, and a classification of the region based annotations and our method of identifying hypermutated regions. We also manually annotated each region by viewing in the UCSC genome browser

From: Identification of coding and non-coding mutational hotspots in cancer genomes

Rank Chr Start End Mutated samples Score Automated annotation Manual annotation
1 chr12 25398250 25398300 256 399.9 Driver KRAS exon
2 chr17 7577100 7577150 68 182.1 Driver TP53 exon
3 chr17 7577500 7577550 62 165.7 Driver TP53 exon
4 chr3 41266100 41266150 65 149.3 Driver CTNNB1 exon
5 chr17 7578400 7578450 50 130.6 Driver TP53 exon
6 chr17 7577550 7577600 41 103.9 Driver TP53 exon
7 chr17 7578200 7578250 32 82.8 Driver TP53 exon
8 chr17 7578250 7578300 31 80.1 Driver TP53 exon
9 chr17 7577050 7577100 29 72.2 Driver TP53 exon
10 chr17 7578500 7578550 26 64.4 driver TP53 exon
11 chr10 96652800 96652850 14 60.0 hotspot non-coding
12 chr12 6899300 6899350 3 57.1 hotspot CD4 intron
13 chr17 7574000 7574050 19 46.2 driver TP53 exon
14 chr17 7578450 7578500 18 43.5 driver TP53 exon
15 chr17 7578350 7578400 17 40.9 driver TP53 exon
16 chr3 195892250 195892300 18 38.7 non-coding non-coding
17 chr17 7577000 7577050 14 38.3 driver TP53 exon
18 chr12 64749950 64750000 7 35.5 hotspot C12orf56 intron
19 chr13 50016900 50016950 8 34.5 hotspot CAB39L intron
20 chr11 63881800 63881850 9 34.4 hotspot FLRT1 intron
21 chr15 64857000 64857050 9 31.6 hotspot ZNF609 intron
22 chr17 7578150 7578200 13 30.6 driver TP53 exon
23 chr17 7578550 7578600 13 30.5 driver TP53 splice site
24 chr16 88383450 88383500 7 28.9 hotspot Non-coding / TF binding
25 chr14 24895100 24895150 11 28.8 hotspot Non-coding / TF binding
26 chr17 79389900 79389950 9 28.8 hotspot BAHCC1 intron
27 chr17 17424850 17424900 7 28.5 hotspot PEMT intron
28 chr22 46697350 46697400 5 27.8 hotspot GTSE1 intron
29 chr8 30717550 30717600 7 27.8 hotspot TEX15 exon-intron border
30 chr7 76949650 76949700 6 27.6 hotspot GSAP intron
31 chr14 74239050 74239100 8 27.2 hotspot ELMSAN1 intron
32 chr4 819750 819800 6 27.0 hotspot CPLX1 intron
33 chr16 81908550 81908600 7 26.4 hotspot PLCG2 intron
34 chr4 39684550 39684600 10 26.4 non-coding non-coding
35 chr22 39962000 39962050 6 26.2 hotspot non-coding
36 chr12 25380250 25380300 20 26.1 driver KRAS exon
37 chr3 43746400 43746450 11 25.4 non-coding ABHD5 intron
38 chr17 7579300 7579350 10 25.4 driver TP53 exon
39 chr9 21971100 21971150 12 24.5 driver CDKN2A exon
40 chr8 9921850 9921900 12 24.3 non-coding MRSA intron
41 chr11 70764100 70764150 6 24.1 hotspot SHANK2 intron
42 chr19 12597300 12597350 9 23.8 hotspot ZNF709 intron
43 chr17 49455750 49455800 10 23.6 hotspot non-coding
44 chr5 1295200 1295250 14 23.4 non-coding TERT promoter
45 chr7 151591800 151591850 6 23.2 hotspot non-coding
46 chr21 44524450 44524500 9 22.9 driver U2AF1 exon
47 chr1 45914900 45914950 7 22.7 hotspot TESK2 intron
48 chr8 29901300 29901350 9 22.4 non-coding non-coding
49 chr7 606050 606100 7 22.0 hotspot PRKAR1B intron
50 chr2 49173750 49173800 27 22.0 non-coding CTCF binding