Fig. 6

A large number of regulatory regions use multiple regulatory modules. a A histogram of the number of regulatory modules used in a regulatory region. b Co-occurring modules partition the regions that use AP-1 modules into distinct functional categories. Left panel: A heatmap showing the region-TF binding matrix of the regions co-bound by AP-1 and enhancer modules, AP-1 and CTCF modules, and AP-1 and promoter modules. The TFs are in the same order as in Fig. 2. Right panel: A heatmap showing the chromatin state annotation of the same regions. E/WE: enhancer/weak enhancer state; CTCF: CTCF state; TSS: TSS/promoter state. c An 80-bp region that contains binding sites assigned to a CTCF module (color in brown) and a promoter module (color in blue). Note that the positions of the sites assigned to different modules are mixed spatially