Fig. 1
From: Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types
Cluster and GO enrichments analysis (a) Graph based on correlation of gene expression highlighting 4 of the most relevant clusters generated by the MCL. Clusters 4 and 6 represented the conserved core cell cycle signature from G1/S transition to mitosis. (b) Average expression profiles of the z-score for each gene within the clusters. Error bars represent standard errors. Dashed lines separate each experiment. Time points, number of experiments and cell types are specified on the x axis. Method of synchronisation is specified by color-coded bars above time points (see legend at the bottom). S, M and G1 phase events are highlighted on the top of the figure. (c) Barplots of three significant GO Biological Process terms after enrichment analysis using DAVID Functional Annotation Chart on the genes found in the respective clusters. Values are negative logarithms of the corrected p-values (Benjamini)