Fig. 7

Genome-wide chromosomal distribution of VL-blood and skin DEGs. (a) Chromosomal locations of the 99 VL-blood DEGs are colored in bold black vertical bars versus the other genes which are grey. The upright bars above and below the parallel lines represent genes either on the forward or reverse strand. Each horizontal black line corresponds to one chromosome. The VL-blood DEGs were mapped to chromosomes with significant stretches, considered transcriptional “hot spots” marked by 6 red boxes. (b) A total of 35 dysregulated VL-blood genes are located in the 6 VL-blood “hot spots” with PSMB8, PSMB9 and TAP1 (bold) on chromosome 6 reported previously as potential VL-associated genetic loci. Subsequently we overlaid the 6 transcriptional “hot spots” from our previous VL-skin analysis (6 blue boxes) on the VL-blood chromosomal map. The chromosome # and locus of each transcriptional “hot spot” from VL blood (red) and skin (blue) is defined. The transcriptionally active “hot spots” on chromosome 6 overlaps between the VL-skin and blood gene expression profiles (yellow). Three additional “hot spots” from the two tissue environments map to the same chromosome but do not overlap with each other (grey)