Table 3 Significantly enriched functions related to cellular metabolism in the set of genes differentially expressed in colonocytes isolated from rats fed a high-protein diet compared to rats fed a normal-protein diet. ‘Genes’ indicates the number of genes differently expressed implicated in the function, ‘Up’ and ‘Down’ indicate the number of genes upregulated and downregulated, respectively
From: Epithelial response to a high-protein diet in rat colon
Biological category Function annotation | p-value | Genes | Up | Down |
|---|---|---|---|---|
Protein synthesis | ||||
Polymerization of protein | 1.08E-04 | 36 | 7 | 31 |
Metabolism of protein | 3.52E-02 | 31 | 2 | 29 |
Oligomerization of protein | 6.50E-05 | 30 | 6 | 24 |
Hetero-oligomerization of protein | 1.69E-03 | 17 | 2 | 15 |
Homo-oligomerization of protein | 2.12E-03 | 14 | 4 | 10 |
Hydrolysis of protein fragment | 4.32E-02 | 12 | 2 | 9 |
Metabolism of peptide | 1.39E-02 | 10 | 0 | 10 |
Translation | 6.87E-03 | 9 | 0 | 9 |
Assembly of protein-protein complex | 5.90E-03 | 8 | 0 | 8 |
Translation of protein | 1.83E-02 | 8 | 0 | 8 |
Folding of protein | 1.29E-03 | 7 | 1 | 6 |
Translation of mRNA | 1.71E-02 | 7 | 0 | 7 |
Metabolism of neutral amino acid | 3.38E-02 | 3 | 0 | 3 |
Transport of D-serine | 9.13E-03 | 2 | 1 | 1 |
Lipid metabolism | ||||
Synthesis of glycolipid | 3.88E-02 | 6 | 1 | 5 |
Beta-oxidation of fatty acid | 4.56E-02 | 6 | 1 | 5 |
Synthesis of long chain fatty acid | 4.81E-02 | 2 | 0 | 2 |
Uptake of long chain fatty acid | 4.81E-02 | 2 | 0 | 2 |
Nucleic acid metabolism | ||||
Metabolism of purine nucleotide | 3.31E-02 | 8 | 0 | 8 |
Metabolism of nucleoside triphosphate | 3.88E-02 | 6 | 0 | 6 |
Transport of nucleoside | 7.52E-03 | 3 | 0 | 3 |
Metabolism of carbohydrate | 3.81E-02 | 28 | 3 | 25 |