Fig. 2

Comparisons of the proteomes of animal-associated infecting (AI, in red), animal-associated colonizing (AC, in light red), and human BSI-associated (from dark to light blue) S. aureus ST398 isolates. This figure was created with the “CGView Comparison Tool” [21]. From the outside to the inside: ring 1, COG classification (see COG definitions in Additional file 4: Table S1) of ORFs shown in ring 2; rings 2 and 3, ORFs; ring 4, COG classification of ORFs shown in ring 3; rings 5 to 10 (in red and light red), the AI and AC genomes; rings 11 and 12 (in dark yellow), the reference genome (HI SA10-17 isolate) and the unusual HI SA14_265 genome; rings 13 to 26 (in blue), all other HI genomes; rings 27 and 28, the %GC content and GC skew, respectively, of the reference genome. Arrows indicate the locations of the φ3-like and MR11-like prophages, the transposon Tn916, and the SCCmec IV type in the SA10-17 genome