Fig. 7

Mutations identified in the ZMELR1 vemurafenib resistant melanoma. a. A subset of the mutations putatively called by the RNA-seq is shown, along with their variant allele frequencies. Only 3 of the 27 tested mutations were shown to have bona-fide mutations in the underlying DNA, as demonstrated by Sanger sequencing of genomic DNA from the ZMEL1 and ZMEL-R1 lines. b. Analysis of these mutations in the TCGA and vemurafenib-resistant melanoma samples shows an enrichment of these in the drug resistant human tumors