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Table 3 Four miRNAsa with greatest pleiotropy across metabolic traits using a cut-off of FDR <0.05 to define significance of association

From: Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors

Gene Symbol Top Gene targetb # Traits at FDR < 0.05 Traits Associated
miR-505-5p Major histocompatibility complex, class I (MR1) 4 All but HDL-C and glucose
miR-197-3p SERTA domain containing 4 (SERTAD4) 4 All but HDL-C and glucose
miR-145-5p ATP-binding cassette, subfamily E, member 1 (ABCE1) 4 All but HDL-C and glucose
miR-328 Transcription factor 7-like 2 (TCF7L2) 4 All but HDL-C and glucose
  1. aFifty miRNAs were associated with 3 traits (all 50 miRNAs were associated with the same 3 traits (HDL-C, DBP, and TG).b Top target from miRDB (