Table 3 Four miRNAsa with greatest pleiotropy across metabolic traits using a cut-off of FDR <0.05 to define significance of association
From: Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors
Gene Symbol | Top Gene targetb | # Traits at FDR < 0.05 | Traits Associated |
|---|---|---|---|
miR-505-5p | Major histocompatibility complex, class I (MR1) | 4 | All but HDL-C and glucose |
miR-197-3p | SERTA domain containing 4 (SERTAD4) | 4 | All but HDL-C and glucose |
miR-145-5p | ATP-binding cassette, subfamily E, member 1 (ABCE1) | 4 | All but HDL-C and glucose |
miR-328 | Transcription factor 7-like 2 (TCF7L2) | 4 | All but HDL-C and glucose |