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Fig. 1 | BMC Genomics

Fig. 1

From: Implications of human evolution and admixture for mitochondrial replacement therapy

Fig. 1

Comparison of nuclear (nDNA) versus mitochondrial (mtDNA) genetic divergence levels. Genetic divergence levels between all pairs of human individuals from the 1KGP were calculated as described in the Materials and Methods. a Multidimensional scaling (MDS) plot showing the evolutionary relationships among the 1KGP individuals based on their nuclear (nDNA) genetic distances. b MDS plot showing the evolutionary relationships among the 1KGP individuals based on their mitochondrial (mtDNA) genetic distances. Mitochondrial haplogroup designations are shown on the plot and macro-haplogroups are indicated by grey circles. For panels A & B, individuals from different populations are color coded as shown in the key. c Density scatterplot showing the regression of nuclear (x-axis) against mitochondrial (y-axis) genetic distances for all pairs of individuals. Denser regions of points are shown in dark blue; outlier points are indicated as black dots. The Spearman correlation coefficient (ρ) and corresponding P-value are shown. d Distribution of the nuclear versus mitochondrial distance-differences. A theoretical normal distribution (red line) is superimposed over the observed distribution (grey bars)

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