Fig. 1
Metabolome differences between young and old human skin. a Correlation analysis of metabolites and donor age. Correlations with |rho| > 0.25 and q < 0.01 are considered significant. b-c Example of metabolites that either decrease (in b) or increase (in c) significantly during aging (q < 0.05; differential analysis old vs young). d Metabolic pathway enrichment analysis on significantly changing ions obtained selecting metabolites with (|log2(fold-change)| > 0.1 and q < 0.05) and the pathways as defined by the Human Metabolome DB (HMDB). Only enriched pathways are listed