Fig. 4

Time-course analysis. a Gene groups based on expression transition between week 8 (adenoma/MIN) and week 10 (early carcinoma); red with value 1 = increased expression, blue with value -1 = decreased expression. b A total of 26 groups of various transition statuses. The group 1 and group 12 were the two representative groups. The LRC (log2 ratio change) is plotted against the three transitions, red lines represent the assumed transitions with value of -1, 1 or 0; grey lines are individual genes; black lines are the median. Constant transition as 0, 1 and -1 indicate positive and negative changes respectively. Numbers are genes in each group. Genes in these two groups showed significant change from adenoma/MIN to early carcinoma, when the malignant transition happens. H: hyperplasia, N: adenoma/MIN, EC: early carcinoma, LC: late carcinoma. c Monotonic time course analysis identified three major groups of genes. d GO Biological Process terms enrichment of the three groups, plotted top four results