Gene expression profiles associated with cigarette smoking and moist snuff consumption

Arimilli, Subhashini; Madahian, Behrouz; Chen, Peter; Marano, Kristin; Prasad, G. L.

doi:10.1186/s12864-017-3565-1

BMC Genomics

Table 3 qRT-PCR validation of expression changes that were unique to either SMK-NTC or SMK-MSC comparison

From: Gene expression profiles associated with cigarette smoking and moist snuff consumption

		SMK vs. MSC		SMK vs. NTC		MSC vs. NTC
Gene Symbol	Gene Name	FC	P-value (adj.)‡	FC	P-value (adj.)‡	FC	P-value (adj.)‡
Unique to SMK vs. NTC
ADRB2	adrenoceptor beta 2	−1.44	0.0037	−1.61	0.0003	−1.11	0.5527
B3GNT7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	−1.13	0.6507	−1.95	0.0358	−1.73	0.2651
CCL4	chemokine (C-C motif) ligand 4	2.67	0.4409	−7.43	0.0815	−19.84	0.254
CCR2^a	C-C motif chemokine receptor 2	−1.13	0.648	1.15	0.4312	1.09	0.741
CD160	CD160 molecule	−1.16	0.4317	−1.64	0.0008	−1.42	0.0572
CST7	cystatin F	−1.52	0.0045	−1.71	0	−1.13	0.5229
DTHD1	death domain containing 1	−1.55	0.0221	−1.57	0.0312	−1.01	0.9647
ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5	−1.03	0.945	−1.41	0.3163	−1.37	0.4482
GPR56	G protein-coupled receptor 56	−1.73	0.0079	−1.78	0.0002	−1.02	0.8987
GZMH	granzyme H	−1.61	0.0234	−1.96	0.0039	−1.22	0.5751
HHEX	hematopoietically expressed homeobox	1.00	0.9664	1.09	0.5279	1.08	0.7028
KLRD1^a	killer cell lectin like receptor D1	−1.36	0.0201	−1.71	0.0001	−1.26	0.2944
KLRF1	killer cell lectin like receptor F1	1.07	0.9335	−1.34	0.5279	−1.43	0.5229
LPAR6	lysophosphatidic acid receptor 6	−1.49	0.0215	−1.07	0.7594	1.39	0.2651
MAF^a	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	1.70	0.0215	−1.30	0.0566	−1.73	0.1712
PRF1	perforin 1	−1.40	0.0091	−1.67	0.0002	−1.19	0.4482
S1PR5^a	sphingosine-1-phosphate receptor 5	1.65	0.0676	−1.82	0.0391	−3.00	0.0284
SH2D1B	SH2 domain containing 1B	−1.16	0.648	−1.70	0.0312	−1.46	0.254
SOCS6	suppressor of cytokine signaling 6	1.05	0.8367	1.12	0.5279	1.06	0.741
TBX21	T-box 21	−1.27	0.0796	−1.52	0.0009	−1.20	0.2997
TFEC^a	transcription factor EC	1.34	0.5993	−1.09	0.8409	−1.46	0.5229
TGFBR3	transforming growth factor beta receptor III [	−1.38	0.0079	−1.60	0.0001	−1.16	0.4726
Unique to SMK vs. MSC
ADM	adrenomedullin	1.66	0.0215	−1.19	0.4309	−1.98	0.0393
SSPN^a	sarcospan	−1.71	0.648	−1.30	0.1379	−1.28	0.5164
AHRR^a	aryl-hydrocarbon receptor repressor	3.54	0.0037	3.11	0.0041	−1.14	0.8324

The expression of AHRR gene was also examined since it has previously been linked to smoking. Bolded values denote microarray changes that were confirmed by qRT-PCR. ^adenotes multiple qRT-PCR probes were tested. Only the best result, with respect to fold change or p-value, is reported here. ‡, p-values were adjusted by Benjamini-Hochberg method for qRT-PCR

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ISSN: 1471-2164

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