Fig. 6

Genomic content of promoters of mESC-specific genes. a Results of k-means clustering of normal tissue gene expression show housekeeping genes (Cluster 24) and tissue-specific genes. b Gene clusters are plotted by average coverage of Alu/B1 repeats and CpG island coverage. Housekeeping genes (Cluster 24) are high in both Alu/B1 coverage and CpG island. mESC specific genes (Cluster 13) are high in Alu/B1, but low in CpG island. Gene Clusters specifically expressed in testis, intestine, and placenta are lower in both. c Devoid of CpG islands, the promoters of Pou5f1 and Nanog are enriched with Alu/B1 elements