Fig. 3

Functional enrichment in comparison to a reference protein set. 3.1. With all annotated Drosophila melanogaster proteins as the reference set, enrichment results are shown for: All annotated Culicinae (A. aegypti + C. quinquefasciatus) proteins (outer ring, labeled “Culicinae”); All annotated Anophelinae proteins (middle ring, labeled “Anophelinae”); Protein families gained in the ten anopheline nodes (inner ring, labeled “Gains”). 3.2. With all annotated Culicinae proteins as the reference set, enrichment results are shown for: All annotated Anophelinae proteins (outer ring, labeled “Anophelinae”); Protein families gained in the ten anopheline nodes (inner ring, labeled “Gains”). 3.3. With all annotated proteins from anopheline non-vectors of Plasmodium falciparum (An. sinensis (C), An. sinensis (S), An. christyi, and An. quadriannulatus) as the reference set, enrichment results are shown for all annotated proteins from anopheline vectors of P. falciparum. 3.4. Using only proteins that are orthologues or paralogues of protein families gained in Node 10 (the gambiae complex), enrichment results are shown for Node 10 vectors of P. falciparum in comparison to Node 10 non-vectors of P. falciparum. MosquitoSlim KEY: a Related to nucleic acid metabolism, b Metabolic process, c Innate immunity, d Cell cycle, e Binding, f Cuticular protein, g Chemosensation, h Other, i Cellular component biogenesis j Cellular membrane, k Insecticide resistance, l Peptide hormones, m Epigenetic, n Salivary