Fig. 1

Pathways and functional networks influenced by nicotine in Sst-neurons. a Up- and down-regulated pathways affected by nicotine. b Interaction network of metabolism related pathways. Red and green circles represent significantly up- and down- regulated pathways by nicotine (P < 0.05), respectively. c Network of up-regulated genes involved in glycerophospholipid (left) and nicotinate and nicotinamide (right) metabolisms after nicotine treatment. Pld1, Pld2 and Paap2b are highly-connected genes with a central role in the network than peripheral genes. c, compound; b, binding/association; a, activation