Fig. 5

Representative genes in selected pathways. a The heat map of DEGs involved in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Paired columns on the left: most of the genes in these pathways are relatively low in Sst-neurons and relatively high in Thy1-neurons with no significant difference in normal condition (Sst vs. Thy1, P > 0.05, n = 3). Paired columns on the right: the differences between Sst- and Thy1- neurons become significant after nicotine administration (Sst + Nic vs. Thy1 + Nic, P = 3.57E-4 for AD, P = 2.43E-3 for PD, n = 3). b The heat map of DEGs in metabolic pathway. Paired columns on the left: comparison of transcripts between Sst- and Thy1- neurons without nicotine (Sst vs. Thy1, P > 0.05, n = 3). Paired columns on the right: comparison of transcripts between Sst- and Thy1- neurons with nicotine (Sst + Nic vs. Thy1 + Nic, P = 3.37E-3, n = 3). Pseudocolor scale (−1.5 to 1.5): green represents low expression and red represents high expression