Fig. 6

TFBS enrichment in different dRE groups. a Each dRE group is shown to have a distinct TFBS enrichment. b CLL-associated mutations in the lost dREs disrupt the binding sites of B-cell TFs. c CLL-associated mutations in the gained dREs generate the binding sites of CLL TFs. The black dots indicate the TFs relevant to CLL, and the grey dots represent the TFs relevant to CLL-related diseases, such as leukemia. The details are given in Additional file 2: Table S8 and S9