Table 1 Predominant enriched GO classes at 24Â h in vit C-treated THP-1 cells
GO Term | Description | Higher hierarchya | P-value* | FDR q-valueb |
|---|---|---|---|---|
GO:0007049 | Cell cycle | Cell cycle | 3.41E-09 | 0.000 |
GO:0000075 | Cell cycle checkpoint | Cell cycle | 1.76E-06 | 0.001 |
GO:0022403 | Cell cycle phase | Biological phase | 8.15E-13 | 0.000 |
GO:0044770 | Cell cycle phase transition | Cell cycle | 2.75E-06 | 0.001 |
GO:0022402 | Cell cycle process | Cell cycle | 6.52E-15 | 0.000 |
GO:0031570 | DNA integrity checkpoint | Cell cycle | 1.33E-05 | 0.004 |
GO:0000082 | G1/S transition of mitotic cell cycle | Cell cycle | 8.40E-05 | 0.019 |
GO:0000279 | M phase | Biological phase | 2.25E-04 | 0.043 |
GO:0000087 | M phase of mitotic cell cycle | Cell cycle | 1.89E-04 | 0.039 |
GO:0007126 | Meiosis | Cell cycle | 3.44E-06 | 0.001 |
GO:0007067 | Mitosis | Cell cycle | 2.06E-04 | 0.041 |
GO:0000278 | Mitotic cell cycle | Cell cycle | 7.08E-13 | 0.000 |
GO:0044772 | Mitotic cell cycle phase transition | Cell cycle | 2.75E-06 | 0.001 |
GO:0000083 | Regulation of transcription involved in G1/S phase of mitotic cell cycle | Cell cycle | 1.34E-06 | 0.001 |
GO:0051320 | S phase | Biological phase | 6.16E-06 | 0.002 |
GO:0000084 | S phase of mitotic cell cycle | Cell cycle | 1.62E-05 | 0.005 |
GO:0032201 | Telomere maintenance via semi-conservative replication | Cell cycle | 5.83E-07 | 0.000 |
GO:0043044 | ATP-dependent chromatin remodeling | Chromosome organization | 5.29E-06 | 0.002 |
GO:0034080 | CENP-A containing nucleosome assembly at centromere | Chromosome organization | 3.34E-07 | 0.000 |
GO:0006333 | Chromatin assembly or disassembly | Chromosome organization | 7.41E-06 | 0.003 |
GO:0031055 | Chromatin remodeling at centromere | Chromosome organization | 4.74E-07 | 0.000 |
GO:0006336 | DNA replication-independent nucleosome assembly | Chromosome organization | 3.34E-07 | 0.000 |
GO:0034724 | DNA replication-independent nucleosome organization | Chromosome organization | 3.34E-07 | 0.000 |
GO:0043486 | Histone exchange | Chromosome organization | 3.12E-06 | 0.001 |
GO:0006334 | Nucleosome assembly | Chromosome organization | 2.18E-06 | 0.001 |
GO:0034728 | Nucleosome organization | Chromosome organization | 3.98E-05 | 0.011 |
GO:0010833 | Telomere maintenance via telomere lengthening | Chromosome organization | 5.60E-05 | 0.014 |
GO:0032200 | Telomere organization | Chromosome organization | 5.83E-05 | 0.014 |
GO:0006259 | DNA metabolic process | DNA metabolic process | 2.44E-10 | 0.000 |
GO:0006310 | DNA recombination | DNA metabolic process | 6.21E-07 | 0.000 |
GO:0006281 | DNA repair | DNA metabolic process | 1.15E-08 | 0.000 |
GO:0006260 | DNA replication | DNA metabolic process | 4.57E-14 | 0.000 |
GO:0006270 | DNA replication initiation | DNA metabolic process | 5.44E-07 | 0.000 |
GO:0022616 | DNA strand elongation | DNA metabolic process | 1.47E-14 | 0.000 |
GO:0006271 | DNA strand elongation involved in DNA replication | DNA metabolic process | 3.82E-15 | 0.000 |
GO:0006268 | DNA unwinding involved in replication | DNA metabolic process | 2.23E-04 | 0.044 |
GO:0006261 | DNA-dependent DNA replication | DNA metabolic process | 2.36E-05 | 0.007 |
GO:0000724 | Double-strand break repair via homologous recombination | DNA metabolic process | 8.53E-06 | 0.003 |
GO:0045005 | Maintenance of fidelity involved in DNA-dependent DNA replication | DNA metabolic process | 9.31E-05 | 0.020 |
GO:0006312 | Mitotic recombination | DNA metabolic process | 7.17E-06 | 0.003 |
GO:0006297 | Nucleotide-excision repair, DNA gap filling | DNA metabolic process | 3.51E-05 | 0.010 |
GO:0000725 | Recombinational repair | DNA metabolic process | 1.28E-05 | 0.004 |
GO:0051052 | Regulation of DNA metabolic process | DNA metabolic process | 1.02E-05 | 0.003 |
GO:0006275 | Regulation of DNA replication | DNA metabolic process | 7.56E-05 | 0.018 |
GO:0000723 | Telomere maintenance | DNA metabolic process | 4.14E-05 | 0.011 |
GO:0000722 | Telomere maintenance via recombination | DNA metabolic process | 2.71E-06 | 0.001 |