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Table 2 The 20 most strongly down-regulated mRNAs in the liver of cows fed grape seed and grape marc meal extract (GSGME) versus control cows at 1 week postpartum

From: Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract

Gene symbol mRNA description FCa P-value
GLCE glucuronic acid epimerase –1.66 0.036
TBATA chromosome 28 open reading frame, human C10orf27 –1.60 0.011
MANF mesencephalic astrocyte-derived neurotrophic factor –1.59 0.014
XBP1 X-box binding protein 1, transcript variant 1 –1.59 0.003
LOC618817 olfactory receptor, family 6, subfamily B, member 2-like –1.55 0.005
SAA4 serum amyloid A4, constitutive –1.54 0.043
HSPA5 heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) –1.51 0.005
GADD45B growth arrest and DNA-damage-inducible, beta –1.51 0.012
WWC1 WW and C2 domain containing 1, transcript variant 2 –1.48 0.037
LOC788587 olfactory receptor, family 4, subfamily D, member 11-like –1.46 0.001
SOCS3 suppressor of cytokine signaling 3 –1.45 0.042
C15H11orf96 chromosome 15 open reading frame, human C11orf96 –1.44 0.018
PHLDA1 pleckstrin homology-like domain, family A, member 1 –1.43 0.012
SDF2L1 stromal cell-derived factor 2-like 1 –1.41 0.012
IRX3 iroquois homeobox 3 –1.40 0.001
LOC784679 peptidylprolyl isomerase A (cyclophilin A)-like –1.39 0.023
HYOU1 hypoxia up-regulated 1, transcript variant 1 –1.39 0.018
ALX3 ALX homeobox 3 –1.39 0.010
CFHR2 complement factor H-related 2 –1.39 0.028
LOC520181 olfactory receptor 5-like –1.39 0.007
  1. aThe FC was calculated from the signal log ratios as follows: 2Signal log ratio if signal log ratio ≥ 0 and (−1) × 2–(Signal log ratio) if signal log ratio < 0. Signal log ratios were calculated from n = 6 microarrays per group