Fig 4

Examples of functional networks of regulated genes shared by different tissues. The 147 differentially expressed genes commonly listed in longissimus muscle, liver, perirenal and subcutaneous adipose tissues were submitted to Ingenuity® Pathway Analysis to visualize small networks of co-expressed genes. Highly-interconnected non-redundant networks were released from specified genes (represented as nodes) and relationships (represented as edges) between them or with neighboring genes were established based on literature records in the Ingenuity® Pathway Knowledge Base. This allows identifying functional networks related to response to oxidative stress, apoptosis, immunity and(or) protein metabolism. Two small functional networks are shown. More networks can be viewed in Additional files 5 and 6. a Relationships through low density lipoproteins (LDL), between SOD2 and PON1 (response to oxidative stress), IL1 and CTSC (immunity) and NTN1 (apoptosis). b Relationship between different molecules acting in protein translation (RPL6, RPL14), protein catabolism (PSMA3, 26S proteasome, and heat-shock proteins HSP70) and protein transport (YWHAZ)