A transcriptome multi-tissue analysis identifies biological pathways and genes associated with variations in feed efficiency of growing pigs

Table 6 Summary of the main adipose tissue-specific biological processes

GO terms^a	Nb DEG	E score	P-value
Subcutaneous adipose tissue
Over-expressed in pigs from the low RFI line
GO:0006796 ~ phosphate metabolic process	14	1.7	0.011
GO:0006006 ~ glucose metabolic process	5	1.6	0.018
GO:0006091 ~ generation of precursor metabolites and energy	11	1.5	0.004
(GO:0016042 ~ lipid catabolic process)	(6)		(0.006)
(GO:0006635 ~ fatty acid beta-oxidation)	(3)		(0.01)
GO:0034599 ~ cellular response to oxidative stress	4	1.2	0.033
Under-expressed in pigs from the low RFI line
GO:0007517 ~ muscle organ development	6	1.7	0.002
GO:0006796 ~ phosphate metabolic process	9	1.3	0.045
GO:0006952 ~ defense response	7	1.2	0.041
Perirenal adipose tissue
Under-expressed in pigs from the low RFI line
GO:0001568 ~ blood vessel development	10	2.8	<0.001
GO:0008202 ~ steroid metabolic process	7	1.4	0.012
(GO:0008203 ~ cholesterol metabolic process)	(4)	1.4	(0.05)

^aGenes that were differentially expressed between pigs from the low or high RFI lines in subcutaneous (SCAT) or perirenal (PRAT) adipose tissues only were clustered according to considered to gene ontology (GO) terms for biological processes and Genomes biological pathways (hsa). Significantly-enriched clusters (E ≥ 1) were listed with the enrichment (E) score, the number (Nb) of differentially expressed genes (DEG) in each cluster and P-value

ISSN: 1471-2164