Table 2 Top 10 canonical pathway

Gαi Signaling

GRM2,GABBR1,CNR1,GRM3,DRD2,GRM4,GNG3,ADCY8,S1PR1,OPRK1,RGS7,HTR1D,ADCY7,ADRA2B,OPRL1,GNB2,GNB5,RGS14,MAPK1,ADORA3,GNG2,ADRA2C,CHRM4,ADRA2A,HRAS

cAMP-mediated signaling

GRM2,PDE4A,GNAO1,GABBR1,CNR1,GRM3,DRD2,GRM4,HTR7,PDE4D,HTR5A,ADCY8,AKAP6,DUSP4,S1PR1,OPRK1,HTR1D,RGS7,ADCY7,CAMK4,ADRA2B,CAMK1D,PPP3CA,OPRL1,PTGER2,RGS14,MAPK1,ADORA3,CAMK1G,ADRA2C,CHRM4,ADRA2A,PDE1A

Glutamate Receptor Signaling

GRM2,GRIA1,GRID1,CAMK4,GRIN2B,GRM3,GRIN3B,SLC1A7,DLG4,GRM4,GRIK4,GRID2,SLC1A6,GNG2,GRIK3

Serotonin Receptor Signaling

HTR1D,ADCY7,DDC,GCH1,HTR2B,TPH1,HTR7,HTR3B,SLC18A1,SLC18A2,HTR5A,SLC18A3,ADCY8

G-Protein Coupled Receptor Signaling

GRM2,PDE4A,GNAO1,GABBR1,CNR1,HRH1,GRM3,GNAQ,DRD2,GRM4,HTR7,PDE4D,HTR5A,ADCY8,DUSP4,S1PR1,PRKCE,OPRK1,HTR1D,RGS7,ADCY7,CAMK4,ADRA2B,SYNGAP1,OPRL1,PTGER2,HTR2B,RGS14,MAPK1,ADORA3,ADRA2C,CHRM4,ADRA2A,HRAS,PDE1A

GABA Receptor Signaling

GABRG2,ADCY7,GABBR1,GPR37,GABRB2,DNM1,NSF,GABRB3,KCNH2,KCNN3,GABRA5,GABRA1,SLC6A1,GABRB1,KCNQ3,ADCY8

Dopamine-DARPP32 Feedback in cAMP Signaling

KCNJ2,PRKG2,KCNJ6,GRIN3B,KCNJ9,GNAQ,DRD2,NOS1,PPP1R14B,PRKCZ,ADCY8,CSNK1E,PRKCE,PPP2R5B,ADCY7,PRKG1,CAMK4,KCNJ14,PPP2R2C,PPP3CA,CACNA1A,GRIN2B,PPP1R14C,KCNJ3,CACNA1C,PRKD1

Neuropathic Pain Signaling In Dorsal Horn Neurons

PRKCE,GRM2,TACR1,GRIA1,GPR37,CAMK4,CAMK1D,GRIN2B,GRM3,KCNH2,GRIN3B,GRM4,KCNN3,MAPK1,PRKD1,NTRK2,CAMK1G,PRKCZ,KCNQ3

Axonal Guidance Signaling

SEMA4D,LINGO1,SRGAP3,GNAO1,SLIT3,SEMA6D,DPYSL5,RGS3,PAK7,TUBB2A,GNAQ,EPHA6,TUBA1A,ARHGEF7,GNG3,ADAM11,RAC3,KLC1,NTRK3,FZD3,NTRK2,PRKCZ,UNC5D,EFNA2,PLXNA3,PRKCE,TUBB,ADAM8,ADAM23,ADAM19,PPP3CA,EPHA7,RTN4R,GNB2,TUBB4A,ADAM22,SLIT2,NGFR,GNB5,PAK6,SHANK2,TUBA1B,MAPK1,NTRK1,PRKD1,GNG2,HRAS,L1CAM

Breast Cancer Regulation by Stathmin1

TUBB2A,GNAQ,TUBA1A,ARHGEF7,PPP1R14B,GNG3,PRKCZ,ADCY8,PRKCE,PPP2R5B,TUBB,ADCY7,CAMK4,CAMK1D,PPP2R2C,STMN1,GNB2,TUBB4A,PPP1R14C,GNB5,TUBA1B,MAPK1,PRKD1,CAMK1G,GNG2,ARHGEF9,HRAS