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Fig. 5 | BMC Genomics

Fig. 5

From: Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs

Fig. 5

Changes in gene expression of secondary metabolite gene clusters in A. chrysogenum. Differential gene expression in A. chrysogenum was examined by pairwise comparison of the production strain with either wild-type or velvet deletion strain. The early cephalosporin C cluster as well as the aphidicolin cluster are given as representative examples. a The expressional changes of the early cephalosporin C cluster and b its genomic organization are given. c Expressional changes of the aphidicolin biosynthesis genes and d organization of cluster associated and adjacent genes. Blue bars represent the expressional change (log2 fold) comparing the industrial strain A3/2 with the wild type ATCC 11550, while orange bars represent the expressional changes induced by the velvet gene deletion. Genes relevant for biosynthesis are indicated in red

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BMC Genomics

ISSN: 1471-2164

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