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Table 1 Top 30 biological processes for which the multi-disorder component of the autism gene set (MDAG) were enriched

From: Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes

Biological process

# MDAG genes

p-Value

FDR

Transmission of nerve impulse

119

1.18E-71

2.18E-68

Synaptic transmission

110

2.53E-70

4.67E-67

Behavior

123

1.07E-59

1.97E-56

Cell-cell signaling

137

7.08E-59

1.31E-55

Regulation of system process

84

2.00E-41

3.70E-38

Neurological system process

164

7.03E-39

1.30E-35

Regulation of neurological system process

57

4.56E-36

8.42E-33

Learning or memory

49

4.57E-35

8.43E-32

Regulation of transmission of nerve impulse

54

8.64E-34

1.59E-30

Regulation of synaptic transmission

51

2.12E-32

3.91E-29

Neuron differentiation

85

2.91E-30

5.38E-27

Neuron development

74

1.13E-29

2.08E-26

Neuron projection development

61

1.40E-26

2.59E-23

Second-messenger-mediated signaling

58

4.18E-26

7.71E-23

Cyclic-nucleotide-mediated signaling

44

7.72E-26

1.43E-22

Cell morphogenesis involved in neuron differentiation

54

2.48E-25

4.57E-22

Cell morphogenesis involved in differentiation

58

3.25E-25

5.99E-22

G-protein signaling, coupled to cyclic nucleotide second messenger

41

4.61E-25

8.51E-22

Learning

31

1.12E-24

2.07E-21

Neuron projection morphogenesis

53

4.86E-24

8.98E-21

Response to endogenous stimulus

73

6.40E-24

1.18E-20

Regulation of secretion

51

1.92E-23

3.54E-20

Axonogenesis

49

1.21E-22

2.23E-19

Feeding behavior

31

2.00E-22

3.69E-19

Response to organic substance

97

5.25E-22

9.70E-19

Intracellular signaling cascade

135

1.40E-21

2.59E-18

Cell projection organization

66

1.65E-21

3.04E-18

Cell projection morphogenesis

53

4.54E-21

8.39E-18

Regulation of cellular localization

53

8.10E-21

1.50E-17

Cell motion

74

2.12E-20

3.92E-17

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BMC Genomics

ISSN: 1471-2164

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