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Table 1 Top 30 biological processes for which the multi-disorder component of the autism gene set (MDAG) were enriched

From: Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes

Biological process # MDAG genes p-Value FDR
Transmission of nerve impulse 119 1.18E-71 2.18E-68
Synaptic transmission 110 2.53E-70 4.67E-67
Behavior 123 1.07E-59 1.97E-56
Cell-cell signaling 137 7.08E-59 1.31E-55
Regulation of system process 84 2.00E-41 3.70E-38
Neurological system process 164 7.03E-39 1.30E-35
Regulation of neurological system process 57 4.56E-36 8.42E-33
Learning or memory 49 4.57E-35 8.43E-32
Regulation of transmission of nerve impulse 54 8.64E-34 1.59E-30
Regulation of synaptic transmission 51 2.12E-32 3.91E-29
Neuron differentiation 85 2.91E-30 5.38E-27
Neuron development 74 1.13E-29 2.08E-26
Neuron projection development 61 1.40E-26 2.59E-23
Second-messenger-mediated signaling 58 4.18E-26 7.71E-23
Cyclic-nucleotide-mediated signaling 44 7.72E-26 1.43E-22
Cell morphogenesis involved in neuron differentiation 54 2.48E-25 4.57E-22
Cell morphogenesis involved in differentiation 58 3.25E-25 5.99E-22
G-protein signaling, coupled to cyclic nucleotide second messenger 41 4.61E-25 8.51E-22
Learning 31 1.12E-24 2.07E-21
Neuron projection morphogenesis 53 4.86E-24 8.98E-21
Response to endogenous stimulus 73 6.40E-24 1.18E-20
Regulation of secretion 51 1.92E-23 3.54E-20
Axonogenesis 49 1.21E-22 2.23E-19
Feeding behavior 31 2.00E-22 3.69E-19
Response to organic substance 97 5.25E-22 9.70E-19
Intracellular signaling cascade 135 1.40E-21 2.59E-18
Cell projection organization 66 1.65E-21 3.04E-18
Cell projection morphogenesis 53 4.54E-21 8.39E-18
Regulation of cellular localization 53 8.10E-21 1.50E-17
Cell motion 74 2.12E-20 3.92E-17