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Table 6 Significant diseases and functions enriched in the biological network (Fig. 3) obtained through Ingenuity® Pathway Analysis (IPA®)

From: Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes

Diseases or functions annotation p-Value Molecules
Proliferation of neuronal cells 1.95E-06 ADAM10, ADCYAP1R1, AKT1, APBB1, APP, CYP19A1, EGFR, ESR1, FKBP4, HBA1/HBA2, MAPK1, MMP2, NDE1, NFATC4, NRP1, Pkc(s), TP53
Growth of neurites 3.24E-06 ADAM10, AKT1, APBB1, APP, CYP19A1, EGFR, ESR1, FKBP4, HBA1/HBA2, MAPK1, MMP2, NFATC4, NRP1, pkc(s), TP53
Interphase of brain cells 8.22E-06 ADCYAP1R1, APP, TP53
Outgrowth of neurites 1.78E-05 ADAM10, AKT1, APBB1, APP, EGFR, ESR1, FKBP4, HBA1/HBA2, MAPK1, NFATC4, NRP1, Pkc(s), TP53
Behavior 1.98E-05 ADAM10, AGAP2, APBB1, APP, CYP19A1, ESR1, HBA1/HBA2, HDC, MAPK1, mir-103, MYBL1, NFATC4, NPPB, Pkc(s), PPP3CB, PRKG1, SHANK2, TP53, TRPV1, UCHL1
Alzheimer’s disease 5.88E-05 ADAM10, APBB1, APP, ESR1, FDFT1, HBA1/HBA2, LSS, mir-103, miR-125b-5p (and other miRNAs w/seed CCUGAG), MMP2, NFATC4, Pkc(s), TP53, UCHL1
Microtubule dynamics 7.64E-05 ABLIM1, ADAM10, AGAP2, AKT1, APP, CYP19A1, DUSP9, EGFR, ESR1, FKBP4, Hsp90, KIF24, MAPK1, NDE1, NFATC4, NRP1, Pkc(s), PPP3CB, PRKG1, PTPRE, TP53, UCHL1
Organization of cytoskeleton 7.78E-05 ABLIM1, ADAM10, AGAP2, AKT1, APP, CYP19A1, DUSP9, EGFR, ESR1, FKBP4, FLNC, Hsp90, KIF24, MAPK1, MGAT5, NDE1, NFATC4, NRP1, Pkc(s), PPP3CB, PRKG1, PTPRE, TP53, UCHL1
Branching of neurites 7.87E-05 ADAM10, AGAP2, AKT1, APP, CYP19A1, NFATC4, NRP1, PRKG1, TP53
Entry into S phase of cerebral cortex cells 1.18E-04 ADCYAP1R1, APP
Anxiety 1.65E-04 ADCYAP1R1, APP, HDC, MAPK1, NFATC4, SHANK2, TRPV1
Branching of cells 1.86E-04 ADAM10, AGAP2, AKT1, APP, BDKRB2, CYP19A1, NFATC4, NRP1, Pkc(s), PRKG1, TP53
Hyperactive behavior 1.92E-04 ADCYAP1R1, AKT1, APP, ESR1, PPP3CB, SHANK2
Development of central nervous system 2.07E-04 ADAM10, ADCYAP1R1, AKT1, APBB1, APP, CYP19A1, EGFR, MAPK1, NDE1, PRKG1, SETD2, TP53, TRPV1
Interphase of neural precursor cells 2.67E-04 ADCYAP1R1, TP53
Conditioning 2.87E-04 ADCYAP1R1, APP, ESR1, MAPK1, MMP2, TRPV1, UCHL1
Firing of neurons 2.97E-04 APP, MAPK1, NPPB, TRPV1
Locomotion 3.09E-04 AGAP2, APP, CYP19A1, ESR1, NFATC4, PPP3CB, TMOD1, TP53, UCHL1
Formation of brain 3.37E-04 ADAM10, ADCYAP1R1, APBB1, APP, CYP19A1, EGFR, NDE1, PRKG1, SETD2, TP53, TRPV1
Cell viability of neuroglia 3.48E-04 AKT1, APP, EGFR, TP53
Cell death of sympathetic neuron 3.96E-04 AGAP2, AKT1, APP, Pkc(s), TP53
Morphogenesis of neurites 4.00E-04 ADAM10, AGAP2, AKT1, APP, CYP19A1, EGFR, NFATC4, NRP1, PRKG1, TP53
Neuritogenesis 4.44E-04 ADAM10, AGAP2, AKT1, APP, CYP19A1, EGFR, NFATC4, NRP1, PRKG1, PTPRE, TP53, UCHL1
Formation of forebrain 5.97E-04 ADAM10, ADCYAP1R1, APBB1, APP, NDE1, PRKG1, SETD2
Migration of neurons 9.72E-04 ADAM10, APBB1, DGCR8, EGFR, NDE1, NRP1, PRKG1
Emotional behavior 1.06E-03 APP, CYP19A1, ESR1, MAPK1, NPPB, SHANK2, TRPV1
Schizophrenia spectrum disorder 1.21E-03 AKT1, APP, EGFR, ESR1, KCNH2, mir-103, Pkc(s), PPP3CB, SHANK2, SMARCA2
Long-term potentiation 1.22E-03 ADCYAP1R1, APP, CYP19A1, EGFR, MAPK1, Pkc(s), SHANK2, TRPV1
Cognition 1.52E-02 AKT1
  1. Our candidate genes are highlighted in bold