Table 6 Significant diseases and functions enriched in the biological network (Fig. 3) obtained through Ingenuity® Pathway Analysis (IPA®)
From: Cross-disorder comparative analysis of comorbid conditions reveals novel autism candidate genes
Diseases or functions annotation | p-Value | Molecules |
|---|---|---|
Proliferation of neuronal cells | 1.95E-06 | ADAM10, ADCYAP1R1, AKT1, APBB1, APP, CYP19A1, EGFR, ESR1, FKBP4, HBA1/HBA2, MAPK1, MMP2, NDE1, NFATC4, NRP1, Pkc(s), TP53 |
Growth of neurites | 3.24E-06 | ADAM10, AKT1, APBB1, APP, CYP19A1, EGFR, ESR1, FKBP4, HBA1/HBA2, MAPK1, MMP2, NFATC4, NRP1, pkc(s), TP53 |
Interphase of brain cells | 8.22E-06 | ADCYAP1R1, APP, TP53 |
Outgrowth of neurites | 1.78E-05 | ADAM10, AKT1, APBB1, APP, EGFR, ESR1, FKBP4, HBA1/HBA2, MAPK1, NFATC4, NRP1, Pkc(s), TP53 |
Behavior | 1.98E-05 | ADAM10, AGAP2, APBB1, APP, CYP19A1, ESR1, HBA1/HBA2, HDC, MAPK1, mir-103, MYBL1, NFATC4, NPPB, Pkc(s), PPP3CB, PRKG1, SHANK2, TP53, TRPV1, UCHL1 |
Alzheimer’s disease | 5.88E-05 | ADAM10, APBB1, APP, ESR1, FDFT1, HBA1/HBA2, LSS, mir-103, miR-125b-5p (and other miRNAs w/seed CCUGAG), MMP2, NFATC4, Pkc(s), TP53, UCHL1 |
Microtubule dynamics | 7.64E-05 | ABLIM1, ADAM10, AGAP2, AKT1, APP, CYP19A1, DUSP9, EGFR, ESR1, FKBP4, Hsp90, KIF24, MAPK1, NDE1, NFATC4, NRP1, Pkc(s), PPP3CB, PRKG1, PTPRE, TP53, UCHL1 |
Organization of cytoskeleton | 7.78E-05 | ABLIM1, ADAM10, AGAP2, AKT1, APP, CYP19A1, DUSP9, EGFR, ESR1, FKBP4, FLNC, Hsp90, KIF24, MAPK1, MGAT5, NDE1, NFATC4, NRP1, Pkc(s), PPP3CB, PRKG1, PTPRE, TP53, UCHL1 |
Branching of neurites | 7.87E-05 | ADAM10, AGAP2, AKT1, APP, CYP19A1, NFATC4, NRP1, PRKG1, TP53 |
Entry into S phase of cerebral cortex cells | 1.18E-04 | ADCYAP1R1, APP |
Anxiety | 1.65E-04 | ADCYAP1R1, APP, HDC, MAPK1, NFATC4, SHANK2, TRPV1 |
Branching of cells | 1.86E-04 | ADAM10, AGAP2, AKT1, APP, BDKRB2, CYP19A1, NFATC4, NRP1, Pkc(s), PRKG1, TP53 |
Hyperactive behavior | 1.92E-04 | ADCYAP1R1, AKT1, APP, ESR1, PPP3CB, SHANK2 |
Development of central nervous system | 2.07E-04 | ADAM10, ADCYAP1R1, AKT1, APBB1, APP, CYP19A1, EGFR, MAPK1, NDE1, PRKG1, SETD2, TP53, TRPV1 |
Interphase of neural precursor cells | 2.67E-04 | ADCYAP1R1, TP53 |
Conditioning | 2.87E-04 | ADCYAP1R1, APP, ESR1, MAPK1, MMP2, TRPV1, UCHL1 |
Firing of neurons | 2.97E-04 | APP, MAPK1, NPPB, TRPV1 |
Locomotion | 3.09E-04 | AGAP2, APP, CYP19A1, ESR1, NFATC4, PPP3CB, TMOD1, TP53, UCHL1 |
Formation of brain | 3.37E-04 | ADAM10, ADCYAP1R1, APBB1, APP, CYP19A1, EGFR, NDE1, PRKG1, SETD2, TP53, TRPV1 |
Cell viability of neuroglia | 3.48E-04 | AKT1, APP, EGFR, TP53 |
Cell death of sympathetic neuron | 3.96E-04 | AGAP2, AKT1, APP, Pkc(s), TP53 |
Morphogenesis of neurites | 4.00E-04 | ADAM10, AGAP2, AKT1, APP, CYP19A1, EGFR, NFATC4, NRP1, PRKG1, TP53 |
Neuritogenesis | 4.44E-04 | ADAM10, AGAP2, AKT1, APP, CYP19A1, EGFR, NFATC4, NRP1, PRKG1, PTPRE, TP53, UCHL1 |
Formation of forebrain | 5.97E-04 | ADAM10, ADCYAP1R1, APBB1, APP, NDE1, PRKG1, SETD2 |
Migration of neurons | 9.72E-04 | ADAM10, APBB1, DGCR8, EGFR, NDE1, NRP1, PRKG1 |
Emotional behavior | 1.06E-03 | APP, CYP19A1, ESR1, MAPK1, NPPB, SHANK2, TRPV1 |
Schizophrenia spectrum disorder | 1.21E-03 | AKT1, APP, EGFR, ESR1, KCNH2, mir-103, Pkc(s), PPP3CB, SHANK2, SMARCA2 |
Long-term potentiation | 1.22E-03 | ADCYAP1R1, APP, CYP19A1, EGFR, MAPK1, Pkc(s), SHANK2, TRPV1 |
Cognition | 1.52E-02 | AKT1 |