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Table 3 Differentially expressed genes between embryos of high and low fertility sires. A subset of 20 enriched genes for each fertility status ranked by the highest to lowest fold change in expression; all detected at an FDR < 1%

From: Male fertility status is associated with DNA methylation signatures in sperm and transcriptomic profiles of bovine preimplantation embryos

Gene symbol Gene name Fold change P-value
Highly expressed in embryos of high fertility sires
 ENSBTAG00000040367   36.63 4.7e−6
 POLL Polymerase (DNA directed), lambda 14.86 6.3e−5
 CYCS Cytochrome C1 somatic 13.85 2.1e-.9
 MEPCE Methylphosphate capping enzyme 8.95 7.9e−5
 TFB2M Transcription factor B2, mitochondria 7.71 6.3e−14
 RPS27 Ribosomal protein S27 7.68 4.7e−10
 APOM Apolipoprotein M 7.57 3.2e−8
 ATP6V0E1 ATPase H+ transporting, lysosomal 9 kDa, V0 subunit e1 6.78 1.3e−11
 SLC25A14 Solute carrier family 25 (mitochondrial carrier, brain) membrane 14 6.32 8.5e−7
 NDUFA1 NADH dehydrogenase (ubiquionone) 1 alpha subcomplex, 7, 14.5 kDA 6.31 1.3e−11
 SFXN4 Sideroflexin 4 5.55 1.3e−7
 RPS20 Ribosomal protein S20 5.53 2.3e−7
 RPS11 Ribosomal protein S11 5.39 1.3e−7
 PSMA1 Proteasome (prosome, macropain) subunit, alpha-type 1 5.25 8.0e−9
 HCFC1R1 Host cell factor c1 regulator (XPO1 dependent) 5.25 1.8e−5
 DDT D-dopa-chrome tautomerase 5.17 4.8e−9
 EBP Emopamil binding protein (sterol isomerase) 5.05 9.3e−10
 GABARAP GABA(A) receptor-associated protein 4.97 9.9e−11
 TMSB10 Thymosin beta 10 4.88 6.2e−8
 ENSBTAG00000006383   4.86 1.2e−9
Highly expressed in embryos of low fertility sires
 ENSBTAG00000046713   205.21 1.0e−6
 TTC37 Tetratricopeptide repeat domain 37 130.66 7.5e−5
 ENSBTAG00000048042   35.43 5.9−5
 ALKBH2 alkB, alkylation repair homolog 2 16.90 4.3e−5
 ENSBTAG00000021503   8.30 1.0e−5
 PHF14 PHD finger protein 14 7.49 5.3e−5
 SREK1 Splicing regulatory glutamine/lysine-rich protein 1 6.19 2.4e−7
 SLC16A7 Solute carrier family 16 (monocarboxylate transporter), member 7 5.73 9.2e−5
 EEA1 Early endosome antigen 1 5.62 4.4e−5
 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIb 5.36 4.6e−5
 ANKRD12 Ankyrin repeat domain 12 4.98 5.7e−7
 ENSBTAG00000011789   4.93 4.0e−5
 SMC4 Structural maintenance of chromosome 4 4.86 9.9e−9
 AKAP9 A kinase (PRKA) anchor protein 9 4.62 3.4e−5
 HMGN5 High mobility group nucleosome binding domain 5 4.57 2.0e−5
 ENSBTAG00000032360   4.55 3.6e−9
 GADD45A Growth arrest and DNA-damage inducible, alpha 4.51 7.7e−5
 SURF2 Surfeit 2 4.33 5.1e−5
 CCDC186 Coiled-coild domain containing 186 4.31 4.2e−5
 NOL7 Nucleolar protein 7, 27kDA 4.28 5.9e−7