Table 3 Differentially expressed genes between embryos of high and low fertility sires. A subset of 20 enriched genes for each fertility status ranked by the highest to lowest fold change in expression; all detected at an FDR < 1%
Gene symbol | Gene name | Fold change | P-value |
|---|---|---|---|
Highly expressed in embryos of high fertility sires | |||
 ENSBTAG00000040367 |  | 36.63 | 4.7e−6 |
 POLL | Polymerase (DNA directed), lambda | 14.86 | 6.3e−5 |
 CYCS | Cytochrome C1 somatic | 13.85 | 2.1e-.9 |
 MEPCE | Methylphosphate capping enzyme | 8.95 | 7.9e−5 |
 TFB2M | Transcription factor B2, mitochondria | 7.71 | 6.3e−14 |
 RPS27 | Ribosomal protein S27 | 7.68 | 4.7e−10 |
 APOM | Apolipoprotein M | 7.57 | 3.2e−8 |
 ATP6V0E1 | ATPase H+ transporting, lysosomal 9 kDa, V0 subunit e1 | 6.78 | 1.3e−11 |
 SLC25A14 | Solute carrier family 25 (mitochondrial carrier, brain) membrane 14 | 6.32 | 8.5e−7 |
 NDUFA1 | NADH dehydrogenase (ubiquionone) 1 alpha subcomplex, 7, 14.5 kDA | 6.31 | 1.3e−11 |
 SFXN4 | Sideroflexin 4 | 5.55 | 1.3e−7 |
 RPS20 | Ribosomal protein S20 | 5.53 | 2.3e−7 |
 RPS11 | Ribosomal protein S11 | 5.39 | 1.3e−7 |
 PSMA1 | Proteasome (prosome, macropain) subunit, alpha-type 1 | 5.25 | 8.0e−9 |
 HCFC1R1 | Host cell factor c1 regulator (XPO1 dependent) | 5.25 | 1.8e−5 |
 DDT | D-dopa-chrome tautomerase | 5.17 | 4.8e−9 |
 EBP | Emopamil binding protein (sterol isomerase) | 5.05 | 9.3e−10 |
 GABARAP | GABA(A) receptor-associated protein | 4.97 | 9.9e−11 |
 TMSB10 | Thymosin beta 10 | 4.88 | 6.2e−8 |
 ENSBTAG00000006383 |  | 4.86 | 1.2e−9 |
Highly expressed in embryos of low fertility sires | |||
 ENSBTAG00000046713 |  | 205.21 | 1.0e−6 |
 TTC37 | Tetratricopeptide repeat domain 37 | 130.66 | 7.5e−5 |
 ENSBTAG00000048042 |  | 35.43 | 5.9−5 |
 ALKBH2 | alkB, alkylation repair homolog 2 | 16.90 | 4.3e−5 |
 ENSBTAG00000021503 |  | 8.30 | 1.0e−5 |
 PHF14 | PHD finger protein 14 | 7.49 | 5.3e−5 |
 SREK1 | Splicing regulatory glutamine/lysine-rich protein 1 | 6.19 | 2.4e−7 |
 SLC16A7 | Solute carrier family 16 (monocarboxylate transporter), member 7 | 5.73 | 9.2e−5 |
 EEA1 | Early endosome antigen 1 | 5.62 | 4.4e−5 |
 BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIb | 5.36 | 4.6e−5 |
 ANKRD12 | Ankyrin repeat domain 12 | 4.98 | 5.7e−7 |
 ENSBTAG00000011789 |  | 4.93 | 4.0e−5 |
 SMC4 | Structural maintenance of chromosome 4 | 4.86 | 9.9e−9 |
 AKAP9 | A kinase (PRKA) anchor protein 9 | 4.62 | 3.4e−5 |
 HMGN5 | High mobility group nucleosome binding domain 5 | 4.57 | 2.0e−5 |
 ENSBTAG00000032360 |  | 4.55 | 3.6e−9 |
 GADD45A | Growth arrest and DNA-damage inducible, alpha | 4.51 | 7.7e−5 |
 SURF2 | Surfeit 2 | 4.33 | 5.1e−5 |
 CCDC186 | Coiled-coild domain containing 186 | 4.31 | 4.2e−5 |
 NOL7 | Nucleolar protein 7, 27kDA | 4.28 | 5.9e−7 |