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Table 5 MBD-Seq identification of DMRs located within genes identified at a FDR of 10%

From: Male fertility status is associated with DNA methylation signatures in sperm and transcriptomic profiles of bovine preimplantation embryos

Gene Chromosome Region Gene length Position in gene DMR P-value
Start site End site
Enriched in high fertility sires
 MMP2 18 23848121–23848499 26,409 19,502 19,880 5.76e−9
 PLEX2 4 96843179–96843579 546,350 268,810 269,211 1.15e−8
 LOC100848700 12 71321184–71321564 178,963 42,786 43,167 1.05e−7
 NXPH1 4 17613149–17613545 374,914 103,807 104,202 1.08e−6
 EML6 11 37358428–37358736 287,064 69,783 70,092 1.34e−6
 PIP4K2A 13 24034672–24034997 185,017 133,799 134,124 2.39e−6
 C5H22orf23 5 110247288–110247609 7926 6034 6356 4.86e−6
 CTCF 18 35289322–35289651 45,637 44,126 44,456 5.76e−6
 LOC100848700 12 71373062–71373461 178,963 94,664 95,064 7.71e−6
 AGBL4 3 9778857–97788873 1,223,677 696,031 696,348 7.98e−6
 MAGI1 22 35613754–35614143 641,540 117,528 117,918 8.03e−6
 ST8SIA1 5 88297961–88298379 180,249 11,094 11,513 9.73e−6
 ANO6 5 35192295–35192666 234,931 135,500 135,872 9.97e−6
 LOC100848700 12 71363838–71364138 178,963 85,440 85,741 1.14e−5
 AAK1 11 67807683–67808077 164,724 7241 7636 1.30e−5
 LOC100848495 24 2838043–2838565 23,590 23,042 23,565 1.44e−5
 PIP4K2A 13 24018939–24019300 185,017 118,066 118,428 1.34e−5
 PKHD1 23 24204511–24204877 458,865 408,928 409,295 1.68e−5
 FGD4 5 77824043–77824292 229,764 220,686 220,936 1.72e−5
Enriched in low fertility sires
 ZFYVE28 6 108448662–108452084 98,584 64,266 67,689 2.56e−9
 KCNK4 29 43213341–43213911 10,180 5101 5672 6.61e−7
 LOC100296550 15 47960292–47960961 2476    3.03e−6
 USP40 3 113785622–113786388 89,524 6993 7760 8.86e−6
 ASPDH 18 57097376–57098221 3087 529 1375 1.16e−5
 NANOS2 18 53852907–53853452 548 23 569 1.98e−5