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Table 5 MBD-Seq identification of DMRs located within genes identified at a FDR of 10%

From: Male fertility status is associated with DNA methylation signatures in sperm and transcriptomic profiles of bovine preimplantation embryos

Gene

Chromosome

Region

Gene length

Position in gene DMR

P-value

Start site

End site

Enriched in high fertility sires

 MMP2

18

23848121–23848499

26,409

19,502

19,880

5.76e−9

 PLEX2

4

96843179–96843579

546,350

268,810

269,211

1.15e−8

 LOC100848700

12

71321184–71321564

178,963

42,786

43,167

1.05e−7

 NXPH1

4

17613149–17613545

374,914

103,807

104,202

1.08e−6

 EML6

11

37358428–37358736

287,064

69,783

70,092

1.34e−6

 PIP4K2A

13

24034672–24034997

185,017

133,799

134,124

2.39e−6

 C5H22orf23

5

110247288–110247609

7926

6034

6356

4.86e−6

 CTCF

18

35289322–35289651

45,637

44,126

44,456

5.76e−6

 LOC100848700

12

71373062–71373461

178,963

94,664

95,064

7.71e−6

 AGBL4

3

9778857–97788873

1,223,677

696,031

696,348

7.98e−6

 MAGI1

22

35613754–35614143

641,540

117,528

117,918

8.03e−6

 ST8SIA1

5

88297961–88298379

180,249

11,094

11,513

9.73e−6

 ANO6

5

35192295–35192666

234,931

135,500

135,872

9.97e−6

 LOC100848700

12

71363838–71364138

178,963

85,440

85,741

1.14e−5

 AAK1

11

67807683–67808077

164,724

7241

7636

1.30e−5

 LOC100848495

24

2838043–2838565

23,590

23,042

23,565

1.44e−5

 PIP4K2A

13

24018939–24019300

185,017

118,066

118,428

1.34e−5

 PKHD1

23

24204511–24204877

458,865

408,928

409,295

1.68e−5

 FGD4

5

77824043–77824292

229,764

220,686

220,936

1.72e−5

Enriched in low fertility sires

 ZFYVE28

6

108448662–108452084

98,584

64,266

67,689

2.56e−9

 KCNK4

29

43213341–43213911

10,180

5101

5672

6.61e−7

 LOC100296550

15

47960292–47960961

2476

  

3.03e−6

 USP40

3

113785622–113786388

89,524

6993

7760

8.86e−6

 ASPDH

18

57097376–57098221

3087

529

1375

1.16e−5

 NANOS2

18

53852907–53853452

548

23

569

1.98e−5