Transcriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress

Table 1 Shared DE genes for Ross vs. Illinois between thermoneutral and heat stress conditions

Gene Symbol	Thermoneutral			Heat Stress			Gene Function
Gene Symbol	P-value	Log₂FC	FDR	P-value	Log₂FC	FDR	Gene Function
STMN1	5.30E-05	1.24	0.023	0.0003	−1.59	0.066	Regulates microtubule dynamics in cell division [105]
CDC45	5.11E-05	1.34	0.023	0.00046	−1.71	0.076	Key replication helicase cofactor in DNA replication [70]
DNA2	7.47E-06	1.71	0.0078	5.99E-05	−2.31	0.030	Essential DNA-helicase for chromosome replication [106]
CCNB2	0.00025	1.17	0.065	0.00042	−1.63	0.075	Important regulator required for cell mitosis [107]
dAK	0.00028	1.46	0.070	1.88E-08	−3.33	0.00011	Crucial regulator for DNA precursor synthesis [108]
MKLP1	6.14E-05	1.10	0.025	0.00046	−1.40	0.076	Mediates cell cycle cytokinesis [109]
CDC20	2.28E-06	1.58	0.0032	0.00029	−1.74	0.065	Regulates chromosome segregation and mitotic exit [110]
SMC2	0.00023	1.32	0.064	2.81E-06	−2.44	0.0042	Essential for chromosome segregation and condensation [111]
FXYD2	1.08E-08	−2.03	6.08E-05	3.36E-09	3.00	3.79E-05	Required for ion transport in heart [112]
SNTB1	7.48E-06	−1.09	0.0078	6.21E-05	1.41	0.030	Involved in muscle contraction [113]
KIAA1210	0.00017	−1.26	0.052	0.00011	1.87	0.046	Unknown
AVD	2.15E-06	−3.55	0.0032	2.05E-05	4.43	0.016	Unknown
AGTR1	0.00012	−3.51	0.041	2.95E-06	6.00	0.0042	Important role in pathogenesis of cardiac hypertrophy [85]
PERP	0.00012	−1.05	0.040	7.78E-06	1.78	0.0098	Mediates p53-dependent apoptosis [114]

ISSN: 1471-2164