Fig. 2

Sequence preference of Cytosine DNA methylation and differentially methylated cytosines in gene elements. (A) Weblogo analysis of bases around ^5m-C in different sequence contexts. X axis represents bases position and Y axis represents the degree of base enrichment. The position of C was defined as 0. (1), (2), (3) represent CG, CHG and CHH context, respectively. a, b, c represent all ^mC sites, high methylation sites and low methylation sites, respectively. In CG context, we defined that methylation level of high methylation level sites was >75% and others were low methylation level sites. In non-CG context, we defined that methylation level of high methylation level sites was >25% and others were low methylation level sites. (B) Methylation level on different genome elements. X axis represents different gene elements, and Y axis represents methylation levels. Each element of each gene was divided into 20 bins and the average of all bins in each Gene element was obtained. Different colours represent different sequence contexts