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Table 3 Selected upregulated genes in the Malpighian tubules following cold acclimation whose putative function in relation to cold tolerance is discussed in the text

From: Effects of cold-acclimation on gene expression in Fall field cricket (Gryllus pennsylvanicus) ionoregulatory tissues

Function

Description

Fold change

P-value

Species

Apoptosis

Caspase-8

2.1

1.7E-5

Zn

Programmed Cell Death Protein 2

2.4

7.0E-10

Nv

Circadian

Clock

2.5

6.4E-9

Gb

Nocturnin

3.5

1.2E-23

Zn

Period

7.6

2.5E-63

Ms

Cytoskeleton

Gamma-Tubulin Complex Component 6

2.2

8.6E-10

Zn

Kinesin-Like Protein Costa

2.8

2.6E-9

Zn

Protein Shroom

2.5

1.6E-9

Zn

Microtubule-Associated Protein Jupiter

2.2

1.8E-8

Zn

Ion transport

Ca2+-Transporting ATPase Type 2C Member 1

2.2

1.1E-8

Zn

Solute Carrier Organic Anion Transporter Family Member 5a1

2.4

3.0E-11

Hs

Phosphorylation

Inositol Polyphosphate Multikinase

2.2

2.6E-15

Zn

Serine Threonine-Protein Kinase rio3

3.4

5.4E-35

Zn

Serine Threonine-Protein Kinase pctaire-2

2.6

3.9E-14

Zn

Serine Threonine-Protein Kinase Tousled-Like 2

2.9

2.7E-11

Zn

Tyrosine-Protein Kinase Transmembrane Receptor ror1

2.5

6.6E-10

Phc

Tyrosine-Protein Phosphatase Non-Receptor Type 23

2.5

1.6E-15

Zn

Protein folding/chaperone

Hsp 70 Family Member

2.0

1.0E-10

Lm

Hsp 70-binding Protein 1

3.3

2.7E-22

Zn

Repair/detoxicant/antioxidant

Alkylated DNA Repair Protein Alkb-Like Protein 4

2.6

1.4E-12

Zn

Cytochrome P450

14.6

3.7E-58

Aa

Cytochrome P450 2j2

3.4

4.6E-7

Zn

Cytochrome P450 partial

6.1

9.1E-11

Zn

DNA Mismatch Repair Protein mlh1

4.2

3.9E-24

Xt

Glutathione S-Transferase Sigma 7

2.3

9.5E-9

Zn

Peroxiredoxin-6

2.1

4.0E-9

Lm

Probable Cytochrome P450 (partial)

6.2

2.6E-13

Tc

Signal transduction

cAMP-Specific 3’,5’-Cyclic Isoform F Isoform X2

3.2

2.4E-30

Tc

G Kinase-Anchoring Protein 1

3.7

1.2E-28

Zn

  1. For a full list of the 999 upregulated Malpighian tubule genes, see Additional file 2: Spreadsheet S1. P-values were adjusted for false discovery rate (FDR). For each gene, the species with the highest sequence similarity via BLAST is given. Species codes: Aa (Aedes aegypti), Gb (Gryllus bimaculatus), Hs (Harpegnathos saltator), Lm (Locusta migratoria), Ms (Modicogryllus siamensis), Nv (Nasonia vitripennis), Phc (Pediculus humanus corporis), Tc (Tribolium castaneum), Xt (Xenopus tropicalis), Zn (Zootermopsis nevadensis)