Hub gene | k.in rank | Association with RFS in the discovery dataset (n = 461) | Association with RFS in the validation dataset (n = 111) | |||||
---|---|---|---|---|---|---|---|---|
HR | 95% CI | p-value | FDR p-value | HR | p-value | CI | ||
CDCA5 | 1 | 0.70 | 0.55–0.89 | 4.32 × 10−3 | 5.51 × 10−3 | 0.69 | 1.66 × 10−1 | 0.40–1.17 |
NCAPH | 2 | 0.67 | 0.52–0.86 | 1.58 × 10−3 | 3.68 × 10−3 | 0.64 | 1.01 × 10−1 | 0.37–.09 |
FEN1 | 4 | 0.68 | 0.52–0.88 | 3.43 × 10−3 | 5.51 × 10−3 | 0.70 | 1.97 × 10−1 | 0.41–1.21 |
MCM2 | 5 | 0.70 | 0.55–0.90 | 4.72 × 10−3 | 5.51 × 10−3 | 0.79 | 3.98 × 10−1 | 0.46–1.36 |
MCM10 | 6 | 0.69 | 0.54–0.90 | 5.95 × 10−3 | 5.95 × 10−3 | 0.73 | 2.72 × 10−1 | 0.41–1.28 |
CENPA | 7 | 0.62 | 0.48–0.81 | 4.40 × 10−4 | 2.80 × 10−3 | 0.53 | 1.46 × 10−2 | 0.31–0.88 |
ZWINT | 9 | 0.64 | 0.50–0.83 | 8.00 × 10−4 | 2.80 × 10−3 | 0.63 | 8.60 × 10−2 | 0.37–1.07 |