Associating transcriptional modules with colon cancer survival through weighted gene co-expression network analysis

Table 2 Relationships between hub genes with RFS in the discovery and validation datasets

Hub gene	k.in rank	Association with RFS in the discovery dataset (n = 461)				Association with RFS in the validation dataset (n = 111)
Hub gene	k.in rank	HR	95% CI	p-value	FDR p-value	HR	p-value	CI
CDCA5	1	0.70	0.55–0.89	4.32 × 10⁻³	5.51 × 10⁻³	0.69	1.66 × 10⁻¹	0.40–1.17
NCAPH	2	0.67	0.52–0.86	1.58 × 10⁻³	3.68 × 10⁻³	0.64	1.01 × 10⁻¹	0.37–.09
FEN1	4	0.68	0.52–0.88	3.43 × 10⁻³	5.51 × 10⁻³	0.70	1.97 × 10⁻¹	0.41–1.21
MCM2	5	0.70	0.55–0.90	4.72 × 10⁻³	5.51 × 10⁻³	0.79	3.98 × 10⁻¹	0.46–1.36
MCM10	6	0.69	0.54–0.90	5.95 × 10⁻³	5.95 × 10⁻³	0.73	2.72 × 10⁻¹	0.41–1.28
CENPA	7	0.62	0.48–0.81	4.40 × 10⁻⁴	2.80 × 10⁻³	0.53	1.46 × 10⁻²	0.31–0.88
ZWINT	9	0.64	0.50–0.83	8.00 × 10⁻⁴	2.80 × 10⁻³	0.63	8.60 × 10⁻²	0.37–1.07

k.in rank: gene rank based on k.in; False discovery rate (FDR); Recurrence-free survival (RFS); Hazard ratios (HRs), 95% confidence intervals (CI), and p-values were calculated using Cox proportional hazard regression analysis treating the gene expression level as a continuous variable

ISSN: 1471-2164