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Table 2 Relationships between hub genes with RFS in the discovery and validation datasets

From: Associating transcriptional modules with colon cancer survival through weighted gene co-expression network analysis

Hub gene k.in rank Association with RFS in the discovery dataset (n = 461) Association with RFS in the validation dataset (n = 111)
HR 95% CI p-value FDR p-value HR p-value CI
CDCA5 1 0.70 0.55–0.89 4.32 × 10−3 5.51 × 10−3 0.69 1.66 × 10−1 0.40–1.17
NCAPH 2 0.67 0.52–0.86 1.58 × 10−3 3.68 × 10−3 0.64 1.01 × 10−1 0.37–.09
FEN1 4 0.68 0.52–0.88 3.43 × 10−3 5.51 × 10−3 0.70 1.97 × 10−1 0.41–1.21
MCM2 5 0.70 0.55–0.90 4.72 × 10−3 5.51 × 10−3 0.79 3.98 × 10−1 0.46–1.36
MCM10 6 0.69 0.54–0.90 5.95 × 10−3 5.95 × 10−3 0.73 2.72 × 10−1 0.41–1.28
CENPA 7 0.62 0.48–0.81 4.40 × 10−4 2.80 × 10−3 0.53 1.46 × 10−2 0.31–0.88
ZWINT 9 0.64 0.50–0.83 8.00 × 10−4 2.80 × 10−3 0.63 8.60 × 10−2 0.37–1.07
  1. k.in rank: gene rank based on k.in; False discovery rate (FDR); Recurrence-free survival (RFS); Hazard ratios (HRs), 95% confidence intervals (CI), and p-values were calculated using Cox proportional hazard regression analysis treating the gene expression level as a continuous variable