Modules

Total gene count

Type 3 (n = 108)

Type 4 (n = 151)


HR

95% CI

pvalue

HR

95% CI

pvalue


Magenta

41

0.99

0.52–1.88

9.78 × 10^{−1}

0.81

0.44–1.46

4.77 × 10^{−1}

Tan

35

0.50

0.26–0.95

3.39 × 10^{−2}

0.90

0.53–1.56

7.17 × 10^{−1}

Green

170

0.74

0.37–1.46

3.83 × 10^{−1}

0.87

0.47–1.60

6.53 × 10^{−1}

Yellow

179

0.38

0.20–0.74

4.46 × 10^{−3}

0.89

0.50–1.58

6.87 × 10^{−1}

Black

82

0.81

0.43–1.54

5.27 × 10^{−1}

0.80

0.45–1.41

4.44 × 10^{−1}

Purple

48

1.46

0.76–2.77

2.54 × 10^{−1}

1.05

0.63–1.76

8.44 × 10^{−1}

Brown

866

1.61

0.92–2.83

9.50 × 10^{−2}

1.38

0.72–2.67

3.34 × 10^{−1}

Red

108

1.74

1.05–2.88

3.02 × 10^{−2}

1.15

0.61–2.18

6.63 × 10^{−1}

Greenyellow

44

1.26

0.59–2.67

5.52 × 10^{−1}

0.95

0.49–1.83

8.73 × 10^{−1}

Blue

369

1.02

0.45–2.34

9.58 × 10^{−1}

1.05

0.53–2.09

8.92 × 10^{−1}

Pink

52

0.51

0.23–1.10

8.57 × 10^{−2}

0.63

0.34–1.20

1.59 × 10^{−1}

 Type 3 definition: MSIlow, CIMPnegative, negative for BRAF mutation, positive for KRAS mutation; Type 4 definition: MSIlow, CIMPnegative, negative for mutations in BRAF and KRAS. False Discovery Rate (FDR); Recurrencefree survival (RFS); Hazard ratios (HRs), 95% confidence intervals (CI), and pvalues were calculated using Cox proportional hazard regression analysis, treating the MEs as continuous variables