Associating transcriptional modules with colon cancer survival through weighted gene co-expression network analysis

Table 3 Relationship between expression modules with RFS within colon cancer molecular subtypes in the discovery dataset

Modules	Total gene count	Type 3 (n = 108)			Type 4 (n = 151)
Modules	Total gene count	HR	95% CI	p-value	HR	95% CI	p-value
Magenta	41	0.99	0.52–1.88	9.78 × 10⁻¹	0.81	0.44–1.46	4.77 × 10⁻¹
Tan	35	0.50	0.26–0.95	3.39 × 10⁻²	0.90	0.53–1.56	7.17 × 10⁻¹
Green	170	0.74	0.37–1.46	3.83 × 10⁻¹	0.87	0.47–1.60	6.53 × 10⁻¹
Yellow	179	0.38	0.20–0.74	4.46 × 10⁻³	0.89	0.50–1.58	6.87 × 10⁻¹
Black	82	0.81	0.43–1.54	5.27 × 10⁻¹	0.80	0.45–1.41	4.44 × 10⁻¹
Purple	48	1.46	0.76–2.77	2.54 × 10⁻¹	1.05	0.63–1.76	8.44 × 10⁻¹
Brown	866	1.61	0.92–2.83	9.50 × 10⁻²	1.38	0.72–2.67	3.34 × 10⁻¹
Red	108	1.74	1.05–2.88	3.02 × 10⁻²	1.15	0.61–2.18	6.63 × 10⁻¹
Green-yellow	44	1.26	0.59–2.67	5.52 × 10⁻¹	0.95	0.49–1.83	8.73 × 10⁻¹
Blue	369	1.02	0.45–2.34	9.58 × 10⁻¹	1.05	0.53–2.09	8.92 × 10⁻¹
Pink	52	0.51	0.23–1.10	8.57 × 10⁻²	0.63	0.34–1.20	1.59 × 10⁻¹

Type 3 definition: MSI-low, CIMP-negative, negative for BRAF mutation, positive for KRAS mutation; Type 4 definition: MSI-low, CIMP-negative, negative for mutations in BRAF and KRAS. False Discovery Rate (FDR); Recurrence-free survival (RFS); Hazard ratios (HRs), 95% confidence intervals (CI), and p-values were calculated using Cox proportional hazard regression analysis, treating the MEs as continuous variables

ISSN: 1471-2164