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Table 3 Relationship between expression modules with RFS within colon cancer molecular subtypes in the discovery dataset

From: Associating transcriptional modules with colon cancer survival through weighted gene co-expression network analysis

Modules Total gene count Type 3 (n = 108) Type 4 (n = 151)
HR 95% CI p-value HR 95% CI p-value
Magenta 41 0.99 0.52–1.88 9.78 × 10−1 0.81 0.44–1.46 4.77 × 10−1
Tan 35 0.50 0.26–0.95 3.39 × 10−2 0.90 0.53–1.56 7.17 × 10−1
Green 170 0.74 0.37–1.46 3.83 × 10−1 0.87 0.47–1.60 6.53 × 10−1
Yellow 179 0.38 0.20–0.74 4.46 × 10−3 0.89 0.50–1.58 6.87 × 10−1
Black 82 0.81 0.43–1.54 5.27 × 10−1 0.80 0.45–1.41 4.44 × 10−1
Purple 48 1.46 0.76–2.77 2.54 × 10−1 1.05 0.63–1.76 8.44 × 10−1
Brown 866 1.61 0.92–2.83 9.50 × 10−2 1.38 0.72–2.67 3.34 × 10−1
Red 108 1.74 1.05–2.88 3.02 × 10−2 1.15 0.61–2.18 6.63 × 10−1
Green-yellow 44 1.26 0.59–2.67 5.52 × 10−1 0.95 0.49–1.83 8.73 × 10−1
Blue 369 1.02 0.45–2.34 9.58 × 10−1 1.05 0.53–2.09 8.92 × 10−1
Pink 52 0.51 0.23–1.10 8.57 × 10−2 0.63 0.34–1.20 1.59 × 10−1
  1. Type 3 definition: MSI-low, CIMP-negative, negative for BRAF mutation, positive for KRAS mutation; Type 4 definition: MSI-low, CIMP-negative, negative for mutations in BRAF and KRAS. False Discovery Rate (FDR); Recurrence-free survival (RFS); Hazard ratios (HRs), 95% confidence intervals (CI), and p-values were calculated using Cox proportional hazard regression analysis, treating the MEs as continuous variables