Fig. 5
From: Pan-cancer analysis reveals technical artifacts in TCGA germline variant calls
Association testing between germline LOF variant burden and cancer type. a Quantile-quantile plots from logistic regression association testing between germline LOF burden and ovarian cancer for three indel filter methods. n = number of genes tested. Red line indicates significant cutoff and red points indicate associations significant p < 1.61 × 10-7. BRCA1/2 associations highlighted. b Number of significant cancer type - gene associations in each cancer type for three indel filter methods. Color indicates cancer types with WGA samples