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Fig. 4 | BMC Genomics

Fig. 4

From: The midgut transcriptome of Aedes aegypti fed with saline or protein meals containing chikungunya virus reveals genes potentially involved in viral midgut escape

Fig. 4

Maximum Relevance Minimum Redundancy (MRMR) expression network of immunity related genes responding to CHIKV infection in midguts of SM and PM fed mosquitoes. The arrows indicate that FREP14 was predicted as the most central immunity gene in CHIKV infected midguts of SM and PM fed mosquitoes when compared to non-infected midguts demonstrating its importance in the innate immune response to CHIKV infection of the mosquito midgut. The centrality score indicated is based on a degree centrality measure, showing how central the gene is to the given network. Differences in the centrality scores underline their role in differentially modulating the cross-talk of immunity genes depending on SM or PM ingestion. Genes used for the network analysis were: FREP14 (AAEL007942), FREP10 (AAEL008646), GNBP4 (AAEL009178), PGRP1 (AAEL009474), FREP37 (AAEL011007), ML26B (AAEL013835), TEP20 (AAEL001794), CECG (AAEL015515), TPX4 (AAEL002309), ATT (AAEL003389), LYSC11 (AAEL003723), DEFC (AAEL003832), DEFD (AAEL003857), FREP9 (AAEL004156), GAM (AAEL004522), CECN (AAEL000621), and CECA (AAEL000627)

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BMC Genomics

ISSN: 1471-2164

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