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Table 1 Bioinformatic characteristics of 12 transmission blocking candidate (surface) antigen genes

From: Identification of candidate transmission-blocking antigen genes in Theileria annulata and related vector-borne apicomplexan parasites

T. annulata ID Chr Product Annotation Signal peptide GPI anchor TMD Macro to mero FC Macro to piro FC Mero to piro FC T. parva ID dN/dS Protein identity Nucleotide identity
TA02580 3 Hypothetical protein 0 2.14 2.74 1.28 TP03_0040 0.0732 28.07 46.00
TA02585 3 Hypothetical protein 0 1.32 2.34 1.77 TP03_0039 0.0127 31.29 47.24
TA03640 * 3 Hypothetical protein Sexual stage antigen (Pfam:PF07422) 0 3.55 4.14 1.17 TP03_0268 0.2529 64.17 73.18
TA03755 3 Sporozoite surface antigen (SPAG) P67 sporozoite (Pfam:PF05642) 1 4.23 4.29 1.01 TP03_0287 0.3260 49.85 63.60
TA10955 * 4 Putative papain-family cysteine protease Cysteine-type peptidase activity (GO:0008234) 0 3.42 4.61 1.35 TP04_0598 0.0904 85.50 83.48
TA13810 2 Putative ts-chitose type 23 kDa piroplasm surface-like protein Orthologous to T. sergenti merozoite surface antigen 1 2.55 1.97 −1.29 TP02_0551 0.1638 83.41 84.57
TA13825 2 Hypothetical protein 1 12.40 11.00 −1.13 TP02_0553 0.4276 49.76 64.30
TA16005 2 Hypothetical protein Domain of unknown function DUF529 (Pfam:PF04385) 1 1.87 3.09 1.65 TP02_0950 0.3317 62.59 75.61
TA16565 1 Hypothetical protein 0 1.60 2.27 1.41 TP01_1144 0.2704 74.68 79.69
TA17050 * 1 Merozoite-piroplasm surface antigen Tams1 Merozoite antigen (Pfam:PF02488) 1 2.62 2.64 1.01 TP01_1056 0.2751 72.86 77.38
TA17220 4 Hypothetical protein Domain of unknown function DUF529 (Pfam:PF04385) 1 1.66 2.81 1.69 TP04_0030 0.3037 51.59 68.65
TA20855 * 1 Hypothetical protein Similarity to P. yoelii (SWALL:EAA20932) and P. falciparum (SWALL:Q8IE86) 0 2.57 2.63 1.03 TP01_0412 0.085 80.43 77.72
  1. Bioinformatic prediction of surface location of 12 candidates genes with significant fold change in gene expression levels between macroschizont and merozoite/piroplasm stages. Candidates selected for allelic sequencing are marked with an asterisk and protein and nucleotide identity are to the putative T. parva orthologue