Skip to main content

Table 5 Top 20 pathway enrichments analysis of the common consensus subnetwork

From: Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort

Pathway Overlap P-value Adjusted P-value Z-score Combined Score Genes
glioma 4/62 7.19E-05 0.002277 −2.14 13.00 PDGFRB; PIK3R1;CALM1;TP53
apoptosis 4/81 1.94E-04 0.002277 −1.85 11.28 CASP8; CFLAR;PIK3R1;TP53
huntingtons disease 3/31 2.20E-04 0.002277 −1.77 10.77 CASP8;CALM1;TP53
colorectal cancer 4/84 2.22E-04 0.002277 −1.84 11.18 PDGFRB; GSK3B;PIK3R1;TP53
prostate cancer 4/86 2.42E-04 0.002277 −1.80 10.97 PDGFRB; GSK3B;PIK3R1;TP53
endometrial cancer 3/52 9.23E-04 0.007232 −1.65 8.13 GSK3B;PIK3R1;TP53
renal cell carcinoma 3/69 2.02E-03 0.01286 −1.61 6.99 GAB1;PIK3R1;HIF1A
melanoma 3/71 2.19E-03 0.01286 −1.49 6.50 PDGFRB;PIK3R1;TP53
erbb signaling pathway 3/85 3.59E-03 0.018769 −1.53 6.08 GSK3B;GAB1;PIK3R1
focal adhesion 4/192 4.51E-03 0.02118 −1.60 6.16 PDGFRB; GSK3B;PIK3R1;RHOA
neurodegenerative diseases 2/38 9.01E-03 0.038512 −0.87 2.83 NGFR;CASP8
non small cell lung cancer 2/53 1.66E-02 0.064347 −1.21 3.32 PIK3R1;TP53
basal cell carcinoma 2/55 1.78E-02 0.064347 −0.92 2.53 GSK3B;TP53
b cell receptor signaling pathway 2/62 2.22E-02 0.074377 −0.91 2.37 GSK3B;PIK3R1
phosphatidylinositol signaling system 2/72 2.91E-02 0.081711 −1.00 2.50 PIK3R1;CALM1
pancreatic cancer 2/73 2.98E-02 0.081711 −0.99 2.49 PIK3R1;TP53
chronic myeloid leukemia 2/75 3.13E-02 0.081711 −0.93 2.33 PIK3R1;TP53
adherens junction 2/75 3.13E-02 0.081711 −0.78 1.96 CSNK2A1;RHOA
regulation of actin cytoskeleton 3/201 3.54E-02 0.087678 −0.96 2.34 PDGFRB; PIK3R1;RHOA
small cell lung cancer 2/85 3.92E-02 0.092081 −0.73 1.74 PIK3R1;TP53
  1. Pathway: The name of KEGG pathway
  2. Overlap: The number of overlapping genes compared with the number of input genes
  3. P-value: P-value was computed using the Fisher exact test
  4. Adjusted P-value: Adjusted P-value was a corrected p-value to the Fisher exact test
  5. Z-score: Computed by assessing the deviation from the expected rank
  6. Combined score: Computed by taking the log of the p-value from the Fish exact test and multiplying that by the z-score of the deviation from the expected rank
  7. Genes: The overlapping genes between the input and the pathway