Table 4 Overview of whole genomea genes with most frequent within-host genetic changes in paired meningococcal carriage isolates. Genes belonging to the core genomeb are highlighted in bold italic
NEIS no | Gene | Gene product | Function | % of pairsc with genetic difference | Mechanisms and percent of pairsd with genetic difference | ||||
|---|---|---|---|---|---|---|---|---|---|
|  |  |  |  | (n = 46) | All STs (n = 46) | ST-11 (n = 5) | ST-53 (n = 4) | ST-192 (n = 23) | ST-2880 (n = 7) |
NEIS0210 | pilE | pilin | Pilin | 85% | GC 85% | no change | GC 75% | GC 96% | GC 100% |
pilS | pilS | pilin | Pilin | 76% | GC 76% | no change | GC 75% | GC 96% | GC 71% |
NEIS2649 | - | hypothetical protein | Unknown | 74% | PM 37%, R 37% | PM 80%, R 20% | R 25% | PM 39%, R 39% | R 57%, PM 14% |
NEIS1310 | modA | type III restriction/modification system methyltransferase | DNA repair | 70% | PV 70% | PV 100% | no change | PV 83% | PV 71% |
NEIS1403 | opaB | opacity protein B | Outer membrane component | 63% | PV 59%, PM 2%, R 2% | PV 20% | PV 50% | PV 78% | PV 29% |
NEIS1719 | opa1800 | outer membrane protein | Outer membrane component | 61% | PV 57%, R 9% | PV 20% | PV 50% | PV 78%, R 9% | PV 29% |
NEIS1655 | relA | GTP pyrophosphokinase | Housekeeping | 47% | PM 43%, R 4% | PM 40% | PM 25% | PM 43%, R 4% | PM 57% |
NEIS0400 | pglH | glycosyltransferase | Protein glycosylation system | 46% | PV 46% | PV 60% | no change | PV 74% | PV 14% |
NEIS0401 | pglG | glycosyltransferase | Protein glycosylation system | 44% | PV 37%, R 7% | PV 40%, R 20% | PV 50% | PV 57%, R 9% | no change |
NEIS0380 | pglI | O-acetyltransferase | Protein glycosylation system | 41% | PV 41% | PV 60% | gene absent | PV 52% | PV 43% |
NEIS1829 | tspA | neisseria-specific antigen protein | Outer membrane component | 41% | R 33%, D 15%, PM 2%, I 2% | no change | D 25%, R 25% | R 61%, D 22%, PM 4% | no change |
NEIS1750 | - | hypothetical protein | Unknown | 37% | PV 35%, PM 2% | PV 20% | no change | PV 43%, PM 4% | PV 29% |
NEIS1946 | hpuA | haemoglobin-haptoglobin utilisation protein | Outer membrane component | 35% | PV 33%, PM 2%, R 2% | PV 40% | no change | PV 52%, PM 4%, R 4% | no change |
NEIS1288 | - | putative aldehyde dehydrogenase | Putative housekeeping | 35% | R 22%, PM 13% | PM 20%, R 20% | PM 75% | R 26% | PM 29%, R 29% |
NEIS1902 | lgtA | lacto-N-neotetraose biosynthesis glycosyl transferase | LOS biosynthesis | 34% | PV 30%, D 4% | no change | no change | PV 61%, D 9% | no change |
NEIS1418 | - | putative membrane peptidase | Putative housekeeping | 33% | D 13%, R 11%, PM 9% | PM 20% | PM 25%, D 25% | D 22%, PM 9%, R 4% | R 57% |
NEIS1852 | emrB | multidrug resistance translocase | Outer membrane component | 33% | PM 24%, R 9% | PM 60% | PM 50%, R 25% | PM 9% | PM 29%, R 29% |