From: Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA
Data set | Method | π 0 a | λ b | #(q < 0.05)c | #(pb < 0.05)d |
---|---|---|---|---|---|
GSE30601 (Gastric cancer, 27 K) | Unadjusted | 0.18 | 25.8 | 21,487 | 8,323 |
SVAe | 0.13 | 59.3 | 23,404 | 13,846 | |
SmartSVA | 0.75 | 1.72 | 888 | 30 | |
RefFreeEWAS | 0.70 | 2.03 | 1,266 | 68 | |
EWASherf | 1.00 | 0.87 | 3 | 1 | |
ReFACTor | 0.95 | 1.07 | 23 | 1 | |
GSE40279 (Human aging, 450 K) | Unadjusted | 0.35 | 7.73 | 245,279 | 41,357 |
SVA | 0.60 | 2.98 | 102,509 | 20,644 | |
SmartSVA | 0.87 | 1.33 | 5,620 | 679 | |
RefFreeEWAS | 0.68 | 2.20 | 43,791 | 5,192 | |
ReFACTor | 0.91 | 1.23 | 1,577 | 177 |