Table 3 Enrichment (GSEA) of top Hallmark Gene Sets for genes over- or underexpressed in the Durophage relative to all other taxa. Genes were pre-ranked by log2 fold change prior to analysis

Name

NES

Pvalue

FDR

Name

NES

Pvalue

FDR

Inflammatory Response

1.74

0.02

0.39

E2F Targets

−2.77

0.00

0

Pancreas Beta Cells

1.65

0.04

0.31

Myc Targets V1

−2.42

0.00

2.74E-03

Uv Response Dn

1.62

0.04

0.23

G2M Checkpoint

-2.35

2.0E-03

0.01

Mitotic Spindle

1.53

0.05

0.27

Oxidative Phosphory.

−2.30

0

4.76E-03

Epith.Mesench.Trans.

1.43

0.10

0.34

Hypoxia

-2.15

2.0E-03

0.01

Myogenesis

1.43

0.08

0.29

Adipogenesis

−1.85

0.01

0.06

Hedgehog Signaling

1.31

0.16

0.38

Protein Secretion

−1.73

0.02

0.11

Kras Signaling Up

1.17

0.26

0.57

Pi3K/Akt/mTOR Sig.

−1.72

0.02

0.10

Il2 Stat5 Signaling

1.12

0.30

0.59

Fatty Acid Metabolism

−1.67

0.04

0.11

Apical Junction

0.94

0.53

0.93

Myc Targets V2

−1.64

0.04

0.12

Name

NES

Pvalue

FDR

Name

NES

Pvalue

FDR

E2F Targets

2.01

0.01

0.12

Hypoxia

−2.42

0.00

0.01

Mitotic Spindle

1.95

0.01

0.08

Tnfa Signaling Via Nfkb

−1.94

0.01

0.09

Myogenesis

1.83

0.01

0.11

Protein Secretion

−1.77

0.01

0.15

Bile Acid Metabolism

1.73

0.03

0.15

Oxidative Phosphorylation

−1.55

0.06

0.31

Inflammatory Response

1.71

0.02

0.13

Epith. Mesench.Trans.

−1.45

0.09

0.40

Interferon Alpha Resp.

1.70

0.02

0.12

Cholesterol Homeostasis

−1.34

0.14

0.53

Myc Targets V1

1.54

0.06

0.22

Il6 Jak Stat3 Signaling

−1.33

0.13

0.46

Dna Repair

1.53

0.06

0.20

Estrogen Response Late

−1.32

0.15

0.42

Uv Response Dn

1.51

0.06

0.20

Kras Signaling Up

−1.31

0.14

0.39

Pi3K/Akt/mTOR Sig.

1.39

0.12

0.30

Estrogen Early Resp.

−1.30

0.16

0.36

Name

NES

Pvalue

FDR

Name

Nes

Pvalue

FDR

Myc Targets V1

3.23

0.00

0.00

Protein Secretion

-2.34

2.1E-03

0.01

E2F Targets

3.16

0.00

0.00

Coagulation

-2.16

1.9E-03

0.02

Allograft Rejection

2.89

0.00

0.00

Uv Response Dn

−1.83

0.02

0.11

Oxidative Phosph.

2.85

0.00

0.00

Estrogen Response Early

−1.80

0.03

0.10

Dna Repair

2.31

0.00

4.3E-03

Estrogen Response Late

−1.78

0.02

0.09

Myc Targets V2

1.90

4.1E-03

0.04

Hypoxia

−1.65

0.04

0.15

G2M Checkpoint

1.82

0.02

0.05

Kras Signaling Dn

−1.58

0.05

0.17

Mitotic Spindle

1.67

0.04

0.10

Notch Signaling

−1.57

0.05

0.16

ROS Pathway

1.61

0.04

0.12

Cholesterol Homeostasis

−1.40

0.09

0.30

Interferon Gamma Resp.

1.40

0.11

0.26

Hedgehog Signaling

−1.38

0.11

0.28

Name

NES

Pvalue

FDR

Name

NES

Pvalue

FDR

Myogenesis

3.59

0.00

0.00

G2M Checkpoint

−4.25

0.00

0.00

Allograft Rejection

3.54

0.00

0.00

E2F Targets

−4.05

0.00

0.00

Interferon Gamma Resp.

2.31

4.0E-03

0.01

Mtorc1 Signaling

−2.97

0.00

0.00

Inflammatory Response

2.16

0

0.01

Cholesterol Homeostasis

−2.69

0.00

2.2E-04

Bile Acid Metabolism

2.06

2.0E-03

0.01

Myc Targets V1

−2.31

0.00

3.5E-03

Il2 Stat5 Signaling

1.94

0.01

0.03

Oxidative Phosphory.

−2.31

0.00

2.9E-03

Interferon Alpha Resp.

1.85

0.01

0.04

Mitotic Spindle

-2.17

1.9E-03

0.01

P53 Pathway

1.82

0.01

0.04

Estrogen Response Late

−1.65

0.04

0.11

Uv Response Dn

1.74

0.02

0.06

Adipogenesis

−1.51

0.06

0.18

Kras Signaling Up

1.73

0.02

0.06

Fatty Acid Metabolism

−1.50

0.06

0.17