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Table 1 Gene ontology analysis of annotated transcripts significantly affected during the onset of puberty in European sea bass testis (Fisher’s exact test with multiple corrections for FDR)

From: Identification of conserved genes triggering puberty in European sea bass males (Dicentrarchus labrax) by microarray expression profiling

GO-term FDR P-value Sample frequency (N = 141) Array frequency (N = 7681) Gene names
Biological process
GO:0007049. Cell cycle 2.0E-7 2.3E-10 36 (25.5%) 594 (7.7%) uhrf2, dmc1, nsl1, ccnd2, kif2c, cenpi, thbs1 , jmy , chaf1b, psmd3, ncapg, rbbp4, syce1, ttk, sycp2, pold3, camk2d , ndc80, aspm, rad9b, aurkb, psmb7, bub3, dtymk, ppef1, cenph, anln, slbp, spc25, nup37, mad2l1bp, ccne2, trip13, cdc28, nsmce2, cenpf
GO:0051301. Cell division 3.8E-2 2.2E-3 11 (7.8%) 212 (2.8%) nup37, nsmce2, anl, aurkb, cenph, aspm, ndc80, mad2l1bp, bub3, ppef1, cdc28
GO:0007059. Chromosome segregation 2.1E-6 2.1E-08 12 (8.5%) 70 (1.0%) nup37, nsmce2, aurkb, cenph, ndc80, kif2c, madl1bp, cenpf, ttk, bub3, syce1, ncapg
GO:0006259. DNA metabolic process 8.0E-3 6.0E-5 20 (14.2%) 401 (5.2%) uhrf2, dmc1, cacybp, jmy , chaf1b, pcna, ncapg, rbbp4, pold3, rfc3, rad9b, cry2 , smarcc2, asf1b, fen1, trip13, ruvbl2, nt5e , mcm3, nsmce2
GO:0010467. Gene expression 2.0E-7 2.6E-10 4 (2.8%) 1658 (21.6%) uhrf2, thbs1 , eed, asf1b
GO:0000003. Reproduction 2.3E-2 4.9E-04 14 (9.9%) 266 (3.5%) tgfbr1 , adamts1 , cenpi, bub3, syce1, ihh , sycp2, dmc1, hsf2bp, amh , trip13, sdf1a, ttk, fosla
GO:0044237. Cellular metabolic process 2.1E-3 1.2E-5 47 (33.3%) 3993 (52%) uhrf2, dmc1, rab6a , hck, cacybp, thbs1 , jmy , chaf1b, pcna, psmd3, ncapg, cry2 , gpd1, cad, rbbp4, nme1, ttk, pold3, camk2d , rfc3, lox , srsf7, rad9b, eed, ifitm2 , fen1, smarcc2, asf1b, nme3, aurkb, shmt1, cpsf3, atp6v0e1, dtymk, nsmce2, ppef1, u2af35, slbp, trip13, lnx1 , fkbp8 , nnt, ruvbl2, tgfbr1 , nt5e , ubr7, mcm3
GO:0050794. Regulation of cellular process 1.1E-2 8.7E-5 29 (20.6%) 2774 (36.1%) bnc1 , ihh , agrp2 , rab6a , thbs1 , c-fosla , psmd3, q2laq1 , amh , ect2, cad, trip13, camk2d , ndc80, rad9b, stat3 , cry2 , sdf1a , ppef1, depdc1b, crabp1, isg20l2, lbr, ap2s1, cyp26a1 , fkbp8 , tfrc, adamts1 , tgfbr1
Molecular function
GO:0043169. Cation binding 2.4E-3 1.4E-5 8 (5.7%) 1434 (18.7%) ihh , mgp , thbs1 , cad, tppp3 , ppef1, slc25a25 , anxa2
GO:0043167. Ion binding 2.4E-3 1.5E-5 8 (5.7%) 1443 (18.8%) ihh , mgp , thbs1 , cad, tppp3 , ppef1, slc25a25 , anxa2
GO:0046872. Metal ion binding 3.2E-3 2.1E-5 8 (5.7%) 1414 (18.4%) ihh , mgp , thbs1 , cad, tppp3 , ppef1, slc25a25 , anxa2
Cellular component
GO:0005634. Nucleus 4.8E-2 4.7E-4 55 (39.0%) 2002 (26.1%) bnc1 , apeh, uhrf2, dmc1, ihh , ccnd2, cacybp, cenpi, jmy , c-fosla , chaf1b, pcna, trhb , sh3bgrl3 , rbbp4, syce1, sycp2, pold3, camk2d , rfc3, ndc80, aspm, lox , srsf7, rad9b, eed, stat3 , cry2 , smarcc2, asf1b, smox , aurkb, shmt1, cpsf3, lbr, psmb7, b9d2, bub3, gfi1 , fen1, ass1, ppef1, u2af35, cenph, chrac1, slbp, nup37, cenpf, mad2l1bp, ccne2, trip13, isg20l2, ruvbl2, mcm3, cdc28
GO:0005694. Chromosome 3.9E-7 6.0E-10 25 (17.7%) 302 (3.9%) uhrf2, dmc1, nsl1, kif2c, cenpi, pcna, ncapg, rbbp4, syce1, pold3, rfc3, ndc80, rad9b, eed, asf1b, aurkb, bub3, u2af35, spc25, nup37, mad2l1bp, ruvbl2, mcm3, nsmce2, cenpf
GO:0000228. Nuclear chromosome 3.5E-4 1.6E-6 11 (7.8%) 89 (1.1%) dmc1, pcna, rbbp4, syce1, pold3, ndc80, rad9b, eed, aurkb, ruvbl2, mcm3
GO:0016020. Membrane 2.0E-7 2.7E-10 14 (9.9%) 2545 (33.1%) bnc1 , ihh , thbs1 , dsg2 , cad, camk2d , slco2a1 , ppef1, rims1, ap2s1, tfrc, tgfbr1 , nt5e , synpo
  1. Genes in bold type correspond to downregulated genes in the microarray whereas up regulated genes appear in normal type
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