Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance

Table 2 Metabolic components of the biomass function

Complex metabolites	• protein, composed of:
	◦ tRNA ligated amino acids (20)*
	• lipid, composed of
	◦ sphingomyelin*
	◦ cholesterol
	◦ phosphatidyl choline
	◦ phosphatidyl ethanoloamine
	◦ triacylglycerides*
	◦ diacyclglycerides*
	◦ phosphatidyl inositol*
	◦ phosphatidyl glycerol*
	◦ acyl phosphatidyl glycerol*
	• reduced and oxidized glutathione*
	• protoheme
Amino Acids	• alanine	• arginine
	• asparagine	• aspartate
	• cysteine	• glutamate
	• glutamine	• glycine
	• histidine	• isoleucine
	• leucine	• lysine
	• methionine	• serine
	• phenylalanine	• proline
	• threonine	• tryptophan
	• tyrosine	• valine
Carbohydrates	• malate*
	• α-ketoglutarate*
Nucleotides	• ATP	• dATP
	• CTP	• dCTP
	• GTP	• dGTP
	• UTP	• dTTP
	• thiamine diphosphate
Excreted metabolites	• lactate*
	• hemozoin*
Vitamins	• pyridoxal
	• 5-phosphate riboflavin
Other	• s-adenosyl l-methionine	• putrescine
	• spermidine	• 2-octaprenyl 6-hydroyphenol
	• f-thf	• mthf
	• thf	• FAD
	• coenzyme-A	• NAD
	• water	• Fe²⁺ & Fe³⁺
	• NADP	• SO⁴
	• NH⁴+

f-thf = formyl tetrahydrofolate; mthf = methyltetrahydrofolate; thf = tetrahydrofolate
*metabolites that have been added to the iPfal17 and are not present in the biomass function of iTH266

ISSN: 1471-2164