Skip to main content

Table 6 Essential reactions unique to sensitive parasites

From: Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance

Reaction Reaction Formula EC Number Reaction Function Genes
2_7_8_3 CDP-choline[c] + ceramide[c] + h[c] = > CMP[c] + sphingomyelin[c] 2.7.8.3 sphingomyelinase 2 in lipid metabolism PFF1210wa
PFF1215w
AMETt2 adenosyl methionine[e] + h[e] = > adenosyl methionine[c] + h[c] - adenosyl methionine import PF11_0334
PFB0435ca
PFE0775ca
PFF1430c
PFL0420w
PFL1515ca
EX_o2(e) O2[e] < => - oxygen exchange -
EX_ptrc(e) putrescine[e] < => - putrescine exchange -
GAT_c diacylglycerol[c] + acyl-coenzyme-A[c] = > coenzyme-A[c] + triacylglycerol[c] 2.3.1.20 diacylglycerol O-acyltransferase in lipid metabolism PFC0995c
GPDDA4 glycerophosphoglycerol [c] + H2O [c] = > glycerol 3-phosphate[c] + glycerol[c] + h[c] 3.1.4.46 glycerophosphodiester phosphodiesterase in lipid metabolism and glycolysis PF14_0060
O2t O2[e] < => O2[c] - oxygen import -
O2tmt O2[m] < => O2[c] - oxygen transport into mitochondria -
PItap phosphate[ap] < => phosphate[c] - phosphate transport into apicoplast -
PTRCt2 h[e] + putrescine[e] = > h[c] + putrescine[c] - putrescine import -
PYK ADP [c] + h[c] + phosphoenol pyruvate[c] = > ATP[c] + pyruvate[c] 2.7.1.40 pyruvate kinase in glycolysis PFF1300w
amet_ex adenosyl methionine[e] < => - adenosyl methionine exchange -
  1. All reactions in table are predicted to be lethal when removed from both Cambodia and Vietnam sensitive models
  2. a, deleted from at least one sensitive model due to expression constraints by MADE localization: [e] extracellular, [c] cytoplasmic, [m] mitochondria, [ap] apicoplast