Table 1 Predicted effect on Ebola VP24-KPNA5 complex stability by mutations in Ebola VP24
From: Investigating Ebola virus pathogenicity using molecular dynamics
Mutation | mCSM stability (ΔΔG - kcal/mol) | mCSM PP affinity (ΔΔG - kcal/mol) | FoldX stability (ΔΔG - kcal/mol) |
|---|---|---|---|
R137A | −0.80 | −1.07 | −0.68 |
Q139A | −0.39 | −0.24 | −0.33 |
F134A,M136A | NA | NA | −7.3 |
R137A,T138A,Q139A | NA | NA | −1.02 |