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Table 5 FNT channels with unique cytoplasmic slit in the closed state

From: Anion-selective Formate/nitrite transporters: taxonomic distribution, phylogenetic analysis and subfamily-specific conservation pattern in prokaryotes

FNT subfamily UniProt IDa (Organism) Cytoplasmic slit residuesb CHI/CVV valuec
YfdC-α I9C2K5 (Novosphingobium sp.)
J8 W598 (Sphingomonas sp.)
K9CVI9 (Sphingobium yanoikuyae)
L8XVV6 (Wohlfahrtiimonas chitiniclastica)
YLTM CHI: +3.7
NirC-α A3WW31 (Nitrobacter sp.)
A4BNG3 (Nitrococcus mobilis)
D5BVC1 (Nitrosococcus halophilus)
I4EJX4 (Nitrolancea hollandica)
Q82WJ4 (Nitrosomonas europaea)
YMTV CHI: +4.1
YfdC-β A5PEF7 (Erythrobacter sp.)
M0BPP6 (Halovivax asiaticus)
VLSV CVV: 407 Ǻ3
  1. aThe unique UniProt Accession ID is given
  2. bThe four residues that form cytoplasmic slit in the closed state of the channel. They correspond to L79 from TM2a, L89 and T91 from Ω-loop and V175 from TM4 of the formate channel (PDB ID: 3KCU). The residue shown in bold moves away from the cytoplasmic slit when the Ω-loop undergoes conformational changes so that FNT channel can make a transition from the closed to open state
  3. cCalculation of Cumulative Hydropathy Index (CHI) and Cumulative vdw Volume (CVV) are described in the text
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