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Table 7 FNT channels with unique central constriction region

From: Anion-selective Formate/nitrite transporters: taxonomic distribution, phylogenetic analysis and subfamily-specific conservation pattern in prokaryotes

FNT subfamily UniProt IDa (Organism) Central constriction residuesb CHI/CVV valuec
Unclassified Q1Q4Z9 (Candidatus Kuenenia stuttgartiensis) YFQS CHI: −2.8
YfdC-α Q0G7B8 (Fulvimarina pelagi) YLHT CHI: −1.4
YfdC-α Q1YI18 (Aurantimonas manganoxydans) YVHT CHI: −1.0
YfdC-α I1ARB3 (Citreicella sp.) YMHA CHI: −0.8
YfdC-β K9AG69 (Brevibacterium casei) FVHI CHI: +8.3
Unclassified Q1PZF5 (Candidatus Kuenenia stuttgartiensis) FIHV CHI: +8.3
NirC-γ B9DL87, B9DLT5 (Staphylococcus carnosus)
B9E993 (Macrococcus caseolyticus)
E8SEZ7 (Staphylococcus pseudintermedius)
E8SFH6 (Staphylococcus pseudintermedius)
G5JLA8 (Staphylococcus simiae)
I7JE48 (Staphylococcus equorum)
K9AHL1, K9ANW4 (Staphylococcus massiliensis)
J9HA25 (Staphylococcus sp.) and 6 more
FFHY CVV: 529 Ǻ3
  1. aThe unique UniProt Accession ID is given
  2. bThe four residues that form central constriction site within the channel. They correspond to F75 from TM2a, F202 from TM5a, H209 from S-loop and A212 from TM5b of the formate channel (PDB ID: 3KCU)
  3. cCalculation of Cumulative Hydropathy Index (CHI) and Cumulative vdw Volume (CVV) are described in the text
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